Screening of Tanzanian plant extracts for their potential inhibitory effect on P-glycoprotein mediated efﬂux

For years, many efforts have been made to discover new drugs using plants as natural screening libraries. In this study, extracts of 43 Tanzanian medicinal plants were screened for their potential inhibitory effect on P‐gp, using the secretory transport of Cyclosporin A (CsA) in the Caco‐2 system as...

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Veröffentlicht in:	Phytotherapy research 2003-05, Vol.17 (5), p.459-464
Hauptverfasser:	Deferme, S., Kamuhabwa, A., Nshimo, C., de Witte, P., Augustijns, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acacia Algorithms Annonaceae Antineoplastic Agents, Phytogenic - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Biological and medical sciences Biological Transport - drug effects Caco-2 Cells - drug effects Caco-2 Cells - metabolism Cyclosporine - metabolism Cyclosporins - pharmacology efﬂux General pharmacology Humans inhibition Medical sciences P-glycoprotein Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extract Plant Extracts - pharmacology Tanzania
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creator	Deferme, S. Kamuhabwa, A. Nshimo, C. de Witte, P. Augustijns, P.
description	For years, many efforts have been made to discover new drugs using plants as natural screening libraries. In this study, extracts of 43 Tanzanian medicinal plants were screened for their potential inhibitory effect on P‐gp, using the secretory transport of Cyclosporin A (CsA) in the Caco‐2 system as a measure of the functionality of P‐gp efﬂux. Two out of these 43 plant extracts (extracts of Annickia kummeriae and Acacia nilotica) appeared to have a modulatory effect on P‐gp related efﬂux carriers. In presence of the extract of Annickia kummeriae, a concentration dependent decrease on the polarity in transport of CsA was observed; the inhibitory effect of this extract on P‐gp was comparable to that of valspodar, a known P‐gp inhibiting agent. The exact nature of the active components of these botanicals remains to be identiﬁed. Copyright © 2003 John Wiley & Sons, Ltd.
doi_str_mv	10.1002/ptr.1173
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Res</addtitle><description>For years, many efforts have been made to discover new drugs using plants as natural screening libraries. In this study, extracts of 43 Tanzanian medicinal plants were screened for their potential inhibitory effect on P‐gp, using the secretory transport of Cyclosporin A (CsA) in the Caco‐2 system as a measure of the functionality of P‐gp efﬂux. Two out of these 43 plant extracts (extracts of Annickia kummeriae and Acacia nilotica) appeared to have a modulatory effect on P‐gp related efﬂux carriers. In presence of the extract of Annickia kummeriae, a concentration dependent decrease on the polarity in transport of CsA was observed; the inhibitory effect of this extract on P‐gp was comparable to that of valspodar, a known P‐gp inhibiting agent. The exact nature of the active components of these botanicals remains to be identiﬁed. Copyright © 2003 John Wiley & Sons, Ltd.</description><subject>Acacia</subject><subject>Algorithms</subject><subject>Annonaceae</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - physiology</subject><subject>Biological and medical sciences</subject><subject>Biological Transport - drug effects</subject><subject>Caco-2 Cells - drug effects</subject><subject>Caco-2 Cells - metabolism</subject><subject>Cyclosporine - metabolism</subject><subject>Cyclosporins - pharmacology</subject><subject>efﬂux</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>inhibition</subject><subject>Medical sciences</subject><subject>P-glycoprotein</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extract</topic><topic>Plant Extracts - pharmacology</topic><topic>Tanzania</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deferme, S.</creatorcontrib><creatorcontrib>Kamuhabwa, A.</creatorcontrib><creatorcontrib>Nshimo, C.</creatorcontrib><creatorcontrib>de Witte, P.</creatorcontrib><creatorcontrib>Augustijns, P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deferme, S.</au><au>Kamuhabwa, A.</au><au>Nshimo, C.</au><au>de Witte, P.</au><au>Augustijns, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Screening of Tanzanian plant extracts for their potential inhibitory effect on P-glycoprotein mediated efﬂux</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. 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subjects	Acacia Algorithms Annonaceae Antineoplastic Agents, Phytogenic - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Biological and medical sciences Biological Transport - drug effects Caco-2 Cells - drug effects Caco-2 Cells - metabolism Cyclosporine - metabolism Cyclosporins - pharmacology efﬂux General pharmacology Humans inhibition Medical sciences P-glycoprotein Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extract Plant Extracts - pharmacology Tanzania
title	Screening of Tanzanian plant extracts for their potential inhibitory effect on P-glycoprotein mediated efﬂux
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