Autoradiographic evidence for the occlusion of rat brain dopamine D3 receptors In vivo

[125I]Iodosulpride binding was studied in frontal rat brain sections by quantitative autoradiography. Using preincubated (= washed) sections, selective labelling and identification of dopamine D3 receptors was obtained using 0.2 nM [125I]iodosulpride in the presence of 100 nM domperidone for the occ...

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Veröffentlicht in:	European journal of pharmacology 1992-08, Vol.218 (2-3), p.373-375
Hauptverfasser:	SCHOTTE, A, JANSSEN, P. F. M, GOMMEREN, W, LUYTEN, W. H. L. M, LEYSEN, J. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biological and medical sciences Brain - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Fundamental and applied biological sciences. Psychology In Vitro Techniques Iodine Radioisotopes Radioligand Assay Rats Receptors, Dopamine - metabolism Receptors, Dopamine D2 Receptors, Dopamine D3 Sulpiride - analogs & derivatives Sulpiride - metabolism Vertebrates: nervous system and sense organs
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