SDZ PSC 833 and SDZ 280–446 are the most active of various resistance-modifying agents in restoring rhodamine-123 retention within multidrug resistant P388 cells

Multidrug resistance (MDR) of tumor cells may result from overexpression of P-glycoprotein (Pgp) but may be down-modulated by resistance-modifying agents (RMAs). The cyclosporin SDZ PSC 833 and the cyclopeptolide SDZ 280–446 were found to be the strongest RMAs known to date for restoring the sensiti...

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Veröffentlicht in:	Anti-cancer drugs 1992-08, Vol.3 (4), p.419-426
Hauptverfasser:	Pourtier-Manzanedo, A, Didier, A D, Muller, C D, Loor, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Cyclosporins - pharmacology Drug Resistance - physiology Flow Cytometry Fluorescent Dyes - metabolism Microscopy, Fluorescence Peptides, Cyclic - pharmacology Rhodamine 123 Rhodamines - metabolism Tumor Cells, Cultured
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