GFAP and nuclear lamins share an epitope recognized by monoclonal antibody J1-31

Monoclonal antibody J1-31 was raised against plaque materials taken from brains of patients who had suffered from multiple sclerosis (MS). Preliminary characterization of the antigen revealed it to be a protein of M w 68–70 kDa with both a cytoplasmic and nuclear localization. Here we report the res...

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Veröffentlicht in:	Brain research 2003-06, Vol.976 (1), p.9-21
Hauptverfasser:	Garcı́a, Dana M., Weigum, Shannon E., Koke, Joseph R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Monoclonal - immunology Biological and medical sciences Brain - metabolism Brain - pathology Brain - ultrastructure Electrophoresis, Polyacrylamide Gel Epitopes Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - chemistry Glial Fibrillary Acidic Protein - immunology Glial Fibrillary Acidic Protein - metabolism Humans Immunohistochemistry Intermediate filament Lamin Type A - immunology Lamin Type A - metabolism Lamin Type B - immunology Lamin Type B - metabolism Lamins - immunology Lamins - metabolism Medical sciences Microscopy, Confocal Molecular Sequence Data Multiple Sclerosis - pathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Nuclear epitope Nuclear lamin Peptide Fragments - chemistry Phosphoprotein Tumor Cells, Cultured
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