Use of Magnetic Resonance Imaging to Analyze the Performance of Hollow-Fiber Bioreactors
Preliminary experiments were described that demonstrate that MRI is an effective tool for the noninvasive study of hollow-fiber bioreactors. Flow-compensated velocity-encoding pulse sequences were successively applied to analyze the velocity patterns in a module operated without cells, with an artif...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 1992-10, Vol.665 (1), p.285-300 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | DONOGHUE, C. BRIDEAU, M. NEWCOMER, P. PANGRLE, B. DiBIASIO, D. WALSH, E. MOORE, S. |
| description | Preliminary experiments were described that demonstrate that MRI is an effective tool for the noninvasive study of hollow-fiber bioreactors. Flow-compensated velocity-encoding pulse sequences were successively applied to analyze the velocity patterns in a module operated without cells, with an artificially induced flow field perturbation. Diffusion damping pulse sequences were also used to spatially resolve regions of cell growth in a bioreactor. These experiments provide the necessary basis from which future flow and spectroscopic studies can be conducted. |
| doi_str_mv | 10.1111/j.1749-6632.1992.tb42592.x |
| format | Article |
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Flow-compensated velocity-encoding pulse sequences were successively applied to analyze the velocity patterns in a module operated without cells, with an artificially induced flow field perturbation. Diffusion damping pulse sequences were also used to spatially resolve regions of cell growth in a bioreactor. 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These experiments provide the necessary basis from which future flow and spectroscopic studies can be conducted.</description><subject>Animals</subject><subject>Biotechnology - instrumentation</subject><subject>Biotechnology - methods</subject><subject>Cell Division</subject><subject>Cells, Cultured</subject><subject>Culture Techniques - instrumentation</subject><subject>Culture Techniques - methods</subject><subject>Diffusion</subject><subject>Magnetic Resonance Imaging - methods</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEtv00AQx1cIVELhIyCtOHBz2Ie9Dy4oBJJWKgVBK6CX1Xo9Gxxsb9l11IRPj42jcmYuc_g_ZvRD6AUlczrMq-2cylxnQnA2p1qzeV_mrBj2_gGa3UsP0YwQKTOlGX-MnqS0JYQylcsTdEJzKgSlM_TtOgEOHn-wmw762uHPkEJnOwf4vLWbutvgPuBFZ5vDb8D9D8CfIPoQ27-WIXgWmibcZau6hIjf1iGCdX2I6Sl65G2T4Nlxn6Lr1fur5Vl28XF9vlxcZC4nqsiky0vvhSO2YLIqPVeCVRWXuVJMV0AqVWpOtOTeV8oB80wLzVjJNYAtcsZP0cup9zaGXztIvWnr5KBpbAdhl4zkTDJBisH4ejK6GFKK4M1trFsbD4YSM2I1WzOyMyM7M2I1R6xmP4SfH6_syhaqf9GJ46C_mfS7uoHDfzSby--LL0yN72VTQ5162N832PjTCMllYb5erg1bX63eLdc35ob_Aba2l4A</recordid><startdate>199210</startdate><enddate>199210</enddate><creator>DONOGHUE, C.</creator><creator>BRIDEAU, M.</creator><creator>NEWCOMER, P.</creator><creator>PANGRLE, B.</creator><creator>DiBIASIO, D.</creator><creator>WALSH, E.</creator><creator>MOORE, S.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199210</creationdate><title>Use of Magnetic Resonance Imaging to Analyze the Performance of Hollow-Fiber Bioreactors</title><author>DONOGHUE, C. ; BRIDEAU, M. ; NEWCOMER, P. ; PANGRLE, B. ; DiBIASIO, D. ; WALSH, E. ; MOORE, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4085-7c4bff6c0a527dbf3862dd3748829de0d8b930973ffd8ce2f296922b39eea5423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biotechnology - instrumentation</topic><topic>Biotechnology - methods</topic><topic>Cell Division</topic><topic>Cells, Cultured</topic><topic>Culture Techniques - instrumentation</topic><topic>Culture Techniques - methods</topic><topic>Diffusion</topic><topic>Magnetic Resonance Imaging - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DONOGHUE, C.</creatorcontrib><creatorcontrib>BRIDEAU, M.</creatorcontrib><creatorcontrib>NEWCOMER, P.</creatorcontrib><creatorcontrib>PANGRLE, B.</creatorcontrib><creatorcontrib>DiBIASIO, D.</creatorcontrib><creatorcontrib>WALSH, E.</creatorcontrib><creatorcontrib>MOORE, S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DONOGHUE, C.</au><au>BRIDEAU, M.</au><au>NEWCOMER, P.</au><au>PANGRLE, B.</au><au>DiBIASIO, D.</au><au>WALSH, E.</au><au>MOORE, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Magnetic Resonance Imaging to Analyze the Performance of Hollow-Fiber Bioreactors</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>1992-10</date><risdate>1992</risdate><volume>665</volume><issue>1</issue><spage>285</spage><epage>300</epage><pages>285-300</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>Preliminary experiments were described that demonstrate that MRI is an effective tool for the noninvasive study of hollow-fiber bioreactors. 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| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 1992-10, Vol.665 (1), p.285-300 |
| issn | 0077-8923 1749-6632 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Biotechnology - instrumentation Biotechnology - methods Cell Division Cells, Cultured Culture Techniques - instrumentation Culture Techniques - methods Diffusion Magnetic Resonance Imaging - methods |
| title | Use of Magnetic Resonance Imaging to Analyze the Performance of Hollow-Fiber Bioreactors |
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