Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

Altered processing of the amyloid precursor protein (APP) is a central event in the formation of amyloid deposits in the brains of individuals with Alzheimer's disease. To investigate whether cellular APP processing is controlled by cell-surface neurotransmitter receptors, human embryonic kidne...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1992-10, Vol.258 (5080), p.304-307
Hauptverfasser:	Nitsch, Roger M., Slack, Barbara E., Wurtman, Richard J., Growdon, John H.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Alkaloids - pharmacology Alzheimer Disease - metabolism Alzheimer's disease Alzheimers disease amyloid Amyloid beta-Protein Precursor - metabolism Amyloidosis Amyloids Atropine Atropine - pharmacology Blotting, Western Brain Chemistry Carbachol - pharmacology Cell culture techniques Cell Line Cell lines Embryo, Mammalian HEK293 cells Humans Kidney Kinetics man Muscarinic antagonists Muscarinic receptors Neurotransmitter receptors Physiological aspects precursors Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein precursors Receptors Receptors, Muscarinic - drug effects Receptors, Muscarinic - genetics Receptors, Muscarinic - physiology Staurosporine Transfection
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