Non-specific influence of chemical modification upon the properties of antithrombin III:Modification of carboxyl groups

The ability of antithrombin III to inhibit thrombin was observed to be rapidly inactivated upon specific modification of carboxyl groups. The loss of activity, upon treatment with nitrotyrosyl ester in the presence of 1-cyclohexyl-3- (2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate, was con...

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Veröffentlicht in:	Thrombosis research 1992-08, Vol.67 (4), p.447-456
Hauptverfasser:	Scully, M.F., Kakkar, V.V., Goodwin, C.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antithrombin III Antithrombin III - analogs & derivatives Antithrombin III - pharmacology Carbodiimides Chromatography, Affinity CME-Carbodiimide - analogs & derivatives Heparin Heparin - metabolism Humans Hydrogen-Ion Concentration Spectrometry, Mass, Fast Atom Bombardment Thrombin - antagonists & inhibitors Thrombin inhibition Tyrosine - analogs & derivatives
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