p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation

The mechanism of p53-dependent apoptosis is still only partly defined. Using early-passage embryonic fibroblasts (MEF) from wild-type (wt), p53 −/− and bax −/− mice, we observe a p53-dependent translocation of Bax to the mitochondria and a release of mitochondrial Cytochrome c during stress-induced...

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Veröffentlicht in:	Cell death and differentiation 2003-04, Vol.10 (4), p.451-460
Hauptverfasser:	Schuler, M, Maurer, U, Goldstein, J C, Breitenbücher, F, Hoffarth, S, Waterhouse, N J, Green, D R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Apoptosis Apoptosis - genetics bcl-2-Associated X Protein Biochemistry Biomedical and Life Sciences Carrier Proteins - genetics Caspases - metabolism Cell Biology Cell cycle Cell Cycle Analysis Cell death Cells, Cultured Cytochrome Cytochrome c Group - metabolism Down-Regulation - drug effects Down-Regulation - genetics Enzyme Inhibitors - pharmacology Fas-Associated Death Domain Protein Fetus Fibroblasts Fibroblasts - cytology Fibroblasts - enzymology Gene Expression Regulation - genetics Genes Immunology Life Sciences Localization Mice Mice, Knockout Mitochondria Mitochondria - enzymology Mitochondria - genetics Mutation original-paper Protein Transport - drug effects Protein Transport - physiology Proteins Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Stem Cells Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics
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