Effect of Harderian Gland-Derived Growth Factor on the Growth of Cornea Stromal Cells
To investigate the physiological role of Harderian glandderived growth factor (HGDGF), the effects of HGDGF and various other growth factors on the growth of cultured guinea pig cornea stromal cells were examined. HGDGF increased the incorporation of [3H]thymidine to 150% of the control (5% fetal ca...
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| Veröffentlicht in: | Cornea 1992-09, Vol.11 (5), p.380-385 |
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| container_title | Cornea |
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| creator | Yokoyama, Yoshiko Kano, Kazutaka Kaji, Kazuhiko Shirama, Kazuhiko Matsuda, Yasushi Namiki, Hideo Seyama, Yousuke |
| description | To investigate the physiological role of Harderian glandderived growth factor (HGDGF), the effects of HGDGF and various other growth factors on the growth of cultured guinea pig cornea stromal cells were examined. HGDGF increased the incorporation of [3H]thymidine to 150% of the control (5% fetal calf serum). The combination of HGDGF with fibroblast growth factors (FGFs) or platelet-derived growth factor enhanced the cell growth over that of either growth factor alone, increasing the incorporation of [3H]thymidine to 180 and 190% of the control, respectively. The combination of HGDGF with transforming growth factor (TGF-(3) decreased the growth to 60% of the control, and epidermal growth factor had no effect on the activity of HGDGF. The growthstimulating activity of HGDGF was inhibited by suramin in a different manner from that of FGFs. These findings suggest that HGDGF binds a specific cell-surface receptor and plays a role in the repair of injured parts of the cornea and in the maintenance of the cornea stromal cells. |
| doi_str_mv | 10.1097/00003226-199209000-00004 |
| format | Article |
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HGDGF increased the incorporation of [3H]thymidine to 150% of the control (5% fetal calf serum). The combination of HGDGF with fibroblast growth factors (FGFs) or platelet-derived growth factor enhanced the cell growth over that of either growth factor alone, increasing the incorporation of [3H]thymidine to 180 and 190% of the control, respectively. The combination of HGDGF with transforming growth factor (TGF-(3) decreased the growth to 60% of the control, and epidermal growth factor had no effect on the activity of HGDGF. The growthstimulating activity of HGDGF was inhibited by suramin in a different manner from that of FGFs. These findings suggest that HGDGF binds a specific cell-surface receptor and plays a role in the repair of injured parts of the cornea and in the maintenance of the cornea stromal cells.</description><identifier>ISSN: 0277-3740</identifier><identifier>EISSN: 1536-4798</identifier><identifier>DOI: 10.1097/00003226-199209000-00004</identifier><identifier>PMID: 1424664</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Animals ; Cell Division - drug effects ; Cell Line ; Cells, Cultured ; Corneal Stroma - cytology ; Corneal Stroma - drug effects ; DNA Replication - drug effects ; Female ; Growth Substances - isolation & purification ; Growth Substances - pharmacology ; Guinea Pigs ; Harderian Gland - physiology</subject><ispartof>Cornea, 1992-09, Vol.11 (5), p.380-385</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4214-38f2b24feb52499a181b24e326903a3ba1f53c09d7356c2b13d1dc699499d5b33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1424664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yokoyama, Yoshiko</creatorcontrib><creatorcontrib>Kano, Kazutaka</creatorcontrib><creatorcontrib>Kaji, Kazuhiko</creatorcontrib><creatorcontrib>Shirama, Kazuhiko</creatorcontrib><creatorcontrib>Matsuda, Yasushi</creatorcontrib><creatorcontrib>Namiki, Hideo</creatorcontrib><creatorcontrib>Seyama, Yousuke</creatorcontrib><title>Effect of Harderian Gland-Derived Growth Factor on the Growth of Cornea Stromal Cells</title><title>Cornea</title><addtitle>Cornea</addtitle><description>To investigate the physiological role of Harderian glandderived growth factor (HGDGF), the effects of HGDGF and various other growth factors on the growth of cultured guinea pig cornea stromal cells were examined. HGDGF increased the incorporation of [3H]thymidine to 150% of the control (5% fetal calf serum). The combination of HGDGF with fibroblast growth factors (FGFs) or platelet-derived growth factor enhanced the cell growth over that of either growth factor alone, increasing the incorporation of [3H]thymidine to 180 and 190% of the control, respectively. The combination of HGDGF with transforming growth factor (TGF-(3) decreased the growth to 60% of the control, and epidermal growth factor had no effect on the activity of HGDGF. The growthstimulating activity of HGDGF was inhibited by suramin in a different manner from that of FGFs. These findings suggest that HGDGF binds a specific cell-surface receptor and plays a role in the repair of injured parts of the cornea and in the maintenance of the cornea stromal cells.</description><subject>Animals</subject><subject>Cell Division - drug effects</subject><subject>Cell Line</subject><subject>Cells, Cultured</subject><subject>Corneal Stroma - cytology</subject><subject>Corneal Stroma - drug effects</subject><subject>DNA Replication - drug effects</subject><subject>Female</subject><subject>Growth Substances - isolation & purification</subject><subject>Growth Substances - pharmacology</subject><subject>Guinea Pigs</subject><subject>Harderian Gland - physiology</subject><issn>0277-3740</issn><issn>1536-4798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UctOwzAQtBColMInIPnELeBX7PiIAm2RKnGAni0ndpRCEhc7oeLvcUkLJ_ZizezMrjULAMToFiMp7lAsSghPsJQEyYiSPcVOwBSnlCdMyOwUTBERIqGCoXNwEcJbVAjByQRMMCOMczYF68eqsmUPXQWX2hvrN7qDi0Z3JnmI4NMauPBu19dwrsveeeg62Nf2SEZb7nxnNXzpvWt1A3PbNOESnFW6Cfbq8M7Aev74mi-T1fPiKb9fJSUjmCU0q0hBWGWLlDApNc5whJYSLhHVtNC4SmmJpBE05SUpMDXYlFzKKDZpQekM3Ixzt959DDb0qt2EMv5Ad9YNQQlKBIqzozAbhaV3IXhbqa3ftNp_KYzUPlF1TFT9JvpD7a3Xhx1D0VrzZxwjjH029neu6a0P782ws17VVjd9rf47FP0Gmwl-sw</recordid><startdate>199209</startdate><enddate>199209</enddate><creator>Yokoyama, Yoshiko</creator><creator>Kano, Kazutaka</creator><creator>Kaji, Kazuhiko</creator><creator>Shirama, Kazuhiko</creator><creator>Matsuda, Yasushi</creator><creator>Namiki, Hideo</creator><creator>Seyama, Yousuke</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199209</creationdate><title>Effect of Harderian Gland-Derived Growth Factor on the Growth of Cornea Stromal Cells</title><author>Yokoyama, Yoshiko ; Kano, Kazutaka ; Kaji, Kazuhiko ; Shirama, Kazuhiko ; Matsuda, Yasushi ; Namiki, Hideo ; Seyama, Yousuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4214-38f2b24feb52499a181b24e326903a3ba1f53c09d7356c2b13d1dc699499d5b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Cell Division - drug effects</topic><topic>Cell Line</topic><topic>Cells, Cultured</topic><topic>Corneal Stroma - cytology</topic><topic>Corneal Stroma - drug effects</topic><topic>DNA Replication - drug effects</topic><topic>Female</topic><topic>Growth Substances - isolation & purification</topic><topic>Growth Substances - pharmacology</topic><topic>Guinea Pigs</topic><topic>Harderian Gland - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yokoyama, Yoshiko</creatorcontrib><creatorcontrib>Kano, Kazutaka</creatorcontrib><creatorcontrib>Kaji, Kazuhiko</creatorcontrib><creatorcontrib>Shirama, Kazuhiko</creatorcontrib><creatorcontrib>Matsuda, Yasushi</creatorcontrib><creatorcontrib>Namiki, Hideo</creatorcontrib><creatorcontrib>Seyama, Yousuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cornea</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokoyama, Yoshiko</au><au>Kano, Kazutaka</au><au>Kaji, Kazuhiko</au><au>Shirama, Kazuhiko</au><au>Matsuda, Yasushi</au><au>Namiki, Hideo</au><au>Seyama, Yousuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Harderian Gland-Derived Growth Factor on the Growth of Cornea Stromal Cells</atitle><jtitle>Cornea</jtitle><addtitle>Cornea</addtitle><date>1992-09</date><risdate>1992</risdate><volume>11</volume><issue>5</issue><spage>380</spage><epage>385</epage><pages>380-385</pages><issn>0277-3740</issn><eissn>1536-4798</eissn><abstract>To investigate the physiological role of Harderian glandderived growth factor (HGDGF), the effects of HGDGF and various other growth factors on the growth of cultured guinea pig cornea stromal cells were examined. HGDGF increased the incorporation of [3H]thymidine to 150% of the control (5% fetal calf serum). The combination of HGDGF with fibroblast growth factors (FGFs) or platelet-derived growth factor enhanced the cell growth over that of either growth factor alone, increasing the incorporation of [3H]thymidine to 180 and 190% of the control, respectively. The combination of HGDGF with transforming growth factor (TGF-(3) decreased the growth to 60% of the control, and epidermal growth factor had no effect on the activity of HGDGF. The growthstimulating activity of HGDGF was inhibited by suramin in a different manner from that of FGFs. These findings suggest that HGDGF binds a specific cell-surface receptor and plays a role in the repair of injured parts of the cornea and in the maintenance of the cornea stromal cells.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>1424664</pmid><doi>10.1097/00003226-199209000-00004</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cornea, 1992-09, Vol.11 (5), p.380-385 |
| issn | 0277-3740 1536-4798 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals Cell Division - drug effects Cell Line Cells, Cultured Corneal Stroma - cytology Corneal Stroma - drug effects DNA Replication - drug effects Female Growth Substances - isolation & purification Growth Substances - pharmacology Guinea Pigs Harderian Gland - physiology |
| title | Effect of Harderian Gland-Derived Growth Factor on the Growth of Cornea Stromal Cells |
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