Rapid chloroquine efflux phenotype in both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum: A correlation of chloroquine sensitivity with energy-dependent drug accumulation

Recent reports suggest that lower levels of chloroquine accumulation in chloroquine-resistant isolates of Plasmodium falciparum are achieved by energy-dependent chloroquine efflux from resistant parasites. In support of this argument, a rapid chloroquine efflux phenotype has been observed in some ch...

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Veröffentlicht in:	Biochemical pharmacology 1992-10, Vol.44 (7), p.1317-1324
Hauptverfasser:	Bray, P.G., Howells, R.E., Ritchie, G.Y., Ward, S.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Chloroquine - metabolism Chloroquine - pharmacology Drug Resistance Hydrogen-Ion Concentration Medical sciences Pharmacology. Drug treatments Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - metabolism Time Factors Verapamil - metabolism
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