Relationships between the chromatographic retention data and the effects of nucleoside derivatives in highly metastatic 3LL cells

The effect of 21 nucleoside derivatives on the [ 3H]-thymidine cellular uptake and on the incorporation into DNA of highly metastatic 3LL (Lewis lung carcinoma) cells has been measured. Hydrophobic and hydrophilic molecular parameters (the adsorption capacity, specific adsorption surface, lipophilic...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1992-07, Vol.10 (7), p.495-500
Hauptverfasser:	Pogány, G., Cserháti, T., Oláh, J., Valkó, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals chromatographic retention parameters Chromatography, Thin Layer DNA, Neoplasm - biosynthesis hydrophobicity Lewis lung carcinoma Lung Neoplasms - metabolism Neoplasm Metastasis Nucleoside derivatives Nucleosides - pharmacology quantitative structure—activity relationships Structure-Activity Relationship Thymidine - metabolism Tumor Cells, Cultured
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