Preparation and characterization of nanofibers containing amorphous drug dispersions generated by electrostatic spinning

We assessed the application of water-soluble polymer-based nanofibers prepared by electrostatic spinning as a means of altering the dissolution rate of the poorly water-soluble drug, itraconazole. Organic solvent-based solutions of itraconazole/HPMC mixtures were electrostatically spun at 16 and 24...

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Veröffentlicht in:	Pharmaceutical research 2003-05, Vol.20 (5), p.810-817
Hauptverfasser:	VERRECK, Geert, CHUN, Iksoo, PEETERS, Jef, ROSENBLATT, Joel, BREWSTER, Marcus E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Bioavailability Biological and medical sciences Calorimetry, Differential Scanning - methods Dissolution Drug Delivery Systems - methods Drug dosages Electric fields Electron Spin Resonance Spectroscopy - methods General pharmacology Itraconazole - chemical synthesis Itraconazole - pharmacokinetics Medical sciences Microscopy, Electron, Scanning - methods Nanotechnology - methods Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymers Scanning electron microscopy Solid solutions Solvents Static Electricity Surfactants
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