Inhibition of DNA polymerases and DNA topoisomerase II by triterpenes produced by plant callus

We found that some triterpene compounds could not only selectively inhibit the activities of mammalian DNA polymerase α (pol α) and β (pol β), but could also potently inhibit DNA topoisomerase II (topo II) [Biochem. J. 350 (2000) 757]. Here, we report that natural triterpenes produced by callus from...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-05, Vol.305 (2), p.365-373
Hauptverfasser:	Mizushina, Yoshiyuki, Ikuta, Akira, Endoh, Kenji, Oshige, Masahiko, Kasai, Nobuyuki, Kamiya, Kohei, Satake, Toshiko, Takazawa, Hiroshi, Morita, Hiromasa, Tomiyasu, Hiroaki, Yoshida, Hiromi, Sugawara, Fumio, Sakaguchi, Kengo
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Polymerase beta - metabolism DNA Polymerase I - metabolism DNA polymerase α and β DNA topoisomerase II DNA Topoisomerases, Type II - metabolism DNA-Directed DNA Polymerase - metabolism Enzyme inhibitor Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Models, Molecular Plants, Medicinal - chemistry Plants, Medicinal - growth & development Structure-Activity Relationship Triterpenes Triterpenes - chemistry Triterpenes - pharmacology
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