Amperometric detection of perphenazine at a carbon fiber micro-disk bundle electrode by capillary zone electrophoresis
A simple method for determination of perphenazine by capillary zone electrophoresis with amperometric detection is described. The optimum conditions of separation and detection are 1.50×10 −3 mol/l Na 2B 4O 7−1.0×10 −3 mol/l NaOH (pH 9.9) for the buffer solution, 18 kV for the separation voltage, 5...
Gespeichert in:
| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2003-06, Vol.789 (2), p.411-415 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 415 |
|---|---|
| container_issue | 2 |
| container_start_page | 411 |
| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
| container_volume | 789 |
| creator | Liu, Daxing Jin, Wenrui |
| description | A simple method for determination of perphenazine by capillary zone electrophoresis with amperometric detection is described. The optimum conditions of separation and detection are 1.50×10
−3 mol/l Na
2B
4O
7−1.0×10
−3 mol/l NaOH (pH 9.9) for the buffer solution, 18 kV for the separation voltage, 5 kV and 5 s for the injection voltage and the injection time, and 0.80 V versus saturated calomel electrode for the detection potential, respectively. The limit of detection is 5.0×10
−8 mol/l or 44 amol (
S/
N=3). The linear range of the calibration curve is 1.00×10
−7 to 1.00×10
−4 mol/l. The relative standard deviation is 1.5% for the migration time and 2.9% for the electrophoretic current at peak maximum. The method is applied to the determination of perphenazine in human urine. |
| doi_str_mv | 10.1016/S1570-0232(03)00074-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73265519</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1570023203000746</els_id><sourcerecordid>73265519</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-eb268f397f9197ec36e7be4f725a76cf9be3a7c031d6c299e7385bb87de03e23</originalsourceid><addsrcrecordid>eNqFkE1PFTEUhhui4Ut-AqYbDSxG-zHTc2dFCAE0IXEhC3dNP05DdWY6tnNJ4Nfby73K0lWbnudt3z6EnHL2iTOuPn_nHbCGCSnOmDxnjEHbqD1yyFcgGwnqx5u6_4sckKNSfjLGgYHcJwdcQCu4FIfk8XKcMacRlxwd9bigW2KaaAq0ns8POJnnOCE1CzXUmWzrLESLmY7R5dT4WH5Ru578gBSHGs7JI7VPlZ3jMJj8RJ_T9G82P6SMJZZ35G0wQ8GT3XpM7m-u76--NHffbr9eXd41rhVsadAKtQqyh9DzHtBJhWCxDSA6A8qF3qI04JjkXjnR9why1Vm7Ao9MopDH5OP22jmn32ssix5jcVh7TZjWRYMUqut4X8FuC9Y_lZIx6DnHsbbXnOmNb_3iW29kaib1i2-tau797oG1HdG_pnaCK_BhB5jizBCymVwsr1wLneLtpsDFlsNq4zFi1sVFnBz6mKs57VP8T5U_uDGfBg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73265519</pqid></control><display><type>article</type><title>Amperometric detection of perphenazine at a carbon fiber micro-disk bundle electrode by capillary zone electrophoresis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Liu, Daxing ; Jin, Wenrui</creator><creatorcontrib>Liu, Daxing ; Jin, Wenrui</creatorcontrib><description>A simple method for determination of perphenazine by capillary zone electrophoresis with amperometric detection is described. The optimum conditions of separation and detection are 1.50×10
−3 mol/l Na
2B
4O
7−1.0×10
−3 mol/l NaOH (pH 9.9) for the buffer solution, 18 kV for the separation voltage, 5 kV and 5 s for the injection voltage and the injection time, and 0.80 V versus saturated calomel electrode for the detection potential, respectively. The limit of detection is 5.0×10
−8 mol/l or 44 amol (
S/
N=3). The linear range of the calibration curve is 1.00×10
−7 to 1.00×10
−4 mol/l. The relative standard deviation is 1.5% for the migration time and 2.9% for the electrophoretic current at peak maximum. The method is applied to the determination of perphenazine in human urine.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/S1570-0232(03)00074-6</identifier><identifier>PMID: 12742132</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Antipsychotic Agents - urine ; Biological and medical sciences ; Calibration ; Carbon - chemistry ; Electrochemistry - methods ; Electrophoresis, Capillary - methods ; General pharmacology ; Humans ; Medical sciences ; Perphenazine ; Perphenazine - urine ; Pharmacology. Drug treatments</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003-06, Vol.789 (2), p.411-415</ispartof><rights>2003 Elsevier Science B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-eb268f397f9197ec36e7be4f725a76cf9be3a7c031d6c299e7385bb87de03e23</citedby><cites>FETCH-LOGICAL-c420t-eb268f397f9197ec36e7be4f725a76cf9be3a7c031d6c299e7385bb87de03e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1570023203000746$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14756149$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12742132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Daxing</creatorcontrib><creatorcontrib>Jin, Wenrui</creatorcontrib><title>Amperometric detection of perphenazine at a carbon fiber micro-disk bundle electrode by capillary zone electrophoresis</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>A simple method for determination of perphenazine by capillary zone electrophoresis with amperometric detection is described. The optimum conditions of separation and detection are 1.50×10
−3 mol/l Na
2B
4O
7−1.0×10
−3 mol/l NaOH (pH 9.9) for the buffer solution, 18 kV for the separation voltage, 5 kV and 5 s for the injection voltage and the injection time, and 0.80 V versus saturated calomel electrode for the detection potential, respectively. The limit of detection is 5.0×10
−8 mol/l or 44 amol (
S/
N=3). The linear range of the calibration curve is 1.00×10
−7 to 1.00×10
−4 mol/l. The relative standard deviation is 1.5% for the migration time and 2.9% for the electrophoretic current at peak maximum. The method is applied to the determination of perphenazine in human urine.</description><subject>Analysis</subject><subject>Antipsychotic Agents - urine</subject><subject>Biological and medical sciences</subject><subject>Calibration</subject><subject>Carbon - chemistry</subject><subject>Electrochemistry - methods</subject><subject>Electrophoresis, Capillary - methods</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Perphenazine</subject><subject>Perphenazine - urine</subject><subject>Pharmacology. Drug treatments</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PFTEUhhui4Ut-AqYbDSxG-zHTc2dFCAE0IXEhC3dNP05DdWY6tnNJ4Nfby73K0lWbnudt3z6EnHL2iTOuPn_nHbCGCSnOmDxnjEHbqD1yyFcgGwnqx5u6_4sckKNSfjLGgYHcJwdcQCu4FIfk8XKcMacRlxwd9bigW2KaaAq0ns8POJnnOCE1CzXUmWzrLESLmY7R5dT4WH5Ru578gBSHGs7JI7VPlZ3jMJj8RJ_T9G82P6SMJZZ35G0wQ8GT3XpM7m-u76--NHffbr9eXd41rhVsadAKtQqyh9DzHtBJhWCxDSA6A8qF3qI04JjkXjnR9why1Vm7Ao9MopDH5OP22jmn32ssix5jcVh7TZjWRYMUqut4X8FuC9Y_lZIx6DnHsbbXnOmNb_3iW29kaib1i2-tau797oG1HdG_pnaCK_BhB5jizBCymVwsr1wLneLtpsDFlsNq4zFi1sVFnBz6mKs57VP8T5U_uDGfBg</recordid><startdate>20030615</startdate><enddate>20030615</enddate><creator>Liu, Daxing</creator><creator>Jin, Wenrui</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030615</creationdate><title>Amperometric detection of perphenazine at a carbon fiber micro-disk bundle electrode by capillary zone electrophoresis</title><author>Liu, Daxing ; Jin, Wenrui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-eb268f397f9197ec36e7be4f725a76cf9be3a7c031d6c299e7385bb87de03e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Analysis</topic><topic>Antipsychotic Agents - urine</topic><topic>Biological and medical sciences</topic><topic>Calibration</topic><topic>Carbon - chemistry</topic><topic>Electrochemistry - methods</topic><topic>Electrophoresis, Capillary - methods</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Perphenazine</topic><topic>Perphenazine - urine</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Daxing</creatorcontrib><creatorcontrib>Jin, Wenrui</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Daxing</au><au>Jin, Wenrui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amperometric detection of perphenazine at a carbon fiber micro-disk bundle electrode by capillary zone electrophoresis</atitle><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2003-06-15</date><risdate>2003</risdate><volume>789</volume><issue>2</issue><spage>411</spage><epage>415</epage><pages>411-415</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>A simple method for determination of perphenazine by capillary zone electrophoresis with amperometric detection is described. The optimum conditions of separation and detection are 1.50×10
−3 mol/l Na
2B
4O
7−1.0×10
−3 mol/l NaOH (pH 9.9) for the buffer solution, 18 kV for the separation voltage, 5 kV and 5 s for the injection voltage and the injection time, and 0.80 V versus saturated calomel electrode for the detection potential, respectively. The limit of detection is 5.0×10
−8 mol/l or 44 amol (
S/
N=3). The linear range of the calibration curve is 1.00×10
−7 to 1.00×10
−4 mol/l. The relative standard deviation is 1.5% for the migration time and 2.9% for the electrophoretic current at peak maximum. The method is applied to the determination of perphenazine in human urine.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12742132</pmid><doi>10.1016/S1570-0232(03)00074-6</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1570-0232 |
| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003-06, Vol.789 (2), p.411-415 |
| issn | 1570-0232 1873-376X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73265519 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis Antipsychotic Agents - urine Biological and medical sciences Calibration Carbon - chemistry Electrochemistry - methods Electrophoresis, Capillary - methods General pharmacology Humans Medical sciences Perphenazine Perphenazine - urine Pharmacology. Drug treatments |
| title | Amperometric detection of perphenazine at a carbon fiber micro-disk bundle electrode by capillary zone electrophoresis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T01%3A29%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Amperometric%20detection%20of%20perphenazine%20at%20a%20carbon%20fiber%20micro-disk%20bundle%20electrode%20by%20capillary%20zone%20electrophoresis&rft.jtitle=Journal%20of%20chromatography.%20B,%20Analytical%20technologies%20in%20the%20biomedical%20and%20life%20sciences&rft.au=Liu,%20Daxing&rft.date=2003-06-15&rft.volume=789&rft.issue=2&rft.spage=411&rft.epage=415&rft.pages=411-415&rft.issn=1570-0232&rft.eissn=1873-376X&rft_id=info:doi/10.1016/S1570-0232(03)00074-6&rft_dat=%3Cproquest_cross%3E73265519%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73265519&rft_id=info:pmid/12742132&rft_els_id=S1570023203000746&rfr_iscdi=true |