Drug discovery with engineered zinc-finger proteins

Key Points C 2 H 2 zinc fingers are the most common DNA-binding motif found in the human genome. The Zif268–DNA crystal structure shows how zinc fingers interact with DNA. The fingers act as modular units (each contacting three to four base pairs of DNA) and the structure reveals which residues shou...

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Veröffentlicht in:	Nature reviews. Drug discovery 2003-05, Vol.2 (5), p.361-368
Hauptverfasser:	Pabo, Carl O, Jamieson, Andrew C, Miller, Jeffrey C
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites Biomedical and Life Sciences Biomedicine Biotechnology Cancer Research Control DNA - chemistry DNA - metabolism Drug Design Drugs Gene expression Gene Expression Regulation Humans Management Medicinal Chemistry Molecular Medicine Nucleotide sequence Pharmaceutical research Pharmacology/Toxicology Physiological aspects Product development Protein Engineering review-article Transcription Factors - metabolism Zinc finger proteins Zinc Fingers
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