Can preconditioning reduce laparoscopy-induced tissue injury?
Pneumoperitoneum (P) created to facilitate laparoscopy (L) is associated with splanchnic perfusion, ischemia/reperfusion (I/R) injury, and oxidative stress. In this randomized controlled experimental study with blind outcome assessment, we evaluated the effect of preconditioning (PRE) on L-induced I...
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| creator | YILMAZ, S KOKEN, T TOKYOL, C KAHRAMAN, A AKBULUT, G SERTESER, M POLAT, C GOKCE, C GOKCE, O |
| description | Pneumoperitoneum (P) created to facilitate laparoscopy (L) is associated with splanchnic perfusion, ischemia/reperfusion (I/R) injury, and oxidative stress. In this randomized controlled experimental study with blind outcome assessment, we evaluated the effect of preconditioning (PRE) on L-induced I/R injury.
The subjects were 40 Sprague-Dawley male rats. P was created in all except controls, using carbondioxide (CO2) insufflation under a pressure of 15 mmHg. PRE consisted of 10 min of P, followed by 10 min of deflation (D). The rats were randomized to the following groups: Group P was subjected to 60 min of P. Group P/D was subjected to 60 min of P, followed by 45 min of D. Group PRE/P was subjected to PRE, followed by 60 min of P. Group PRE/P/D was subjected to PRE, followed by 60 min of P and 45 min of D. Group C (control) was subjected to a sham operation, without P. Its anesthesia time was equal to that for group PRE/P/D. At the end of the experiments, the rats were killed; blood, liver, and kidney samples were then obtained and coded. Plasma alanine aminotransferase (ALT) and malondialdehyde (MDA), as well as homogenized tissue MDA levels and glutathione (GSH) activities, were measured; tissue samples were assessed for histopathological evidence of injury; all assessments were done by investigators blinded to the study design. The results were decoded and analyzed statistically with the Kruskal-Wallis and Mann Whitney tests. A p |
| doi_str_mv | 10.1007/s00464-002-9096-z |
| format | Article |
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The subjects were 40 Sprague-Dawley male rats. P was created in all except controls, using carbondioxide (CO2) insufflation under a pressure of 15 mmHg. PRE consisted of 10 min of P, followed by 10 min of deflation (D). The rats were randomized to the following groups: Group P was subjected to 60 min of P. Group P/D was subjected to 60 min of P, followed by 45 min of D. Group PRE/P was subjected to PRE, followed by 60 min of P. Group PRE/P/D was subjected to PRE, followed by 60 min of P and 45 min of D. Group C (control) was subjected to a sham operation, without P. Its anesthesia time was equal to that for group PRE/P/D. At the end of the experiments, the rats were killed; blood, liver, and kidney samples were then obtained and coded. Plasma alanine aminotransferase (ALT) and malondialdehyde (MDA), as well as homogenized tissue MDA levels and glutathione (GSH) activities, were measured; tissue samples were assessed for histopathological evidence of injury; all assessments were done by investigators blinded to the study design. The results were decoded and analyzed statistically with the Kruskal-Wallis and Mann Whitney tests. A p <0.05 was considered significant.
Plasma ALT as well as plasma, liver, and kidney MDA levels and liver and kidney injury scores were increased, whereas liver and kidney GSH values were decreased in groups P and P/D, as compared to group C. Rats subjected to PRE before P had plasma ALT, kidney MDA, and kidney and liver GSH levels comparable to controls; their kidney and liver injury scores were higher than controls but significantly lower than nonpreconditioned animals. PRE enabled decreased plasma, kidney, and liver MDA as well as increased kidney GSH if applied before P; its efficacy on oxidative stress was limited to providing decreased kidney MDA and increased kidney GSH if applied before P/D. However, PRE significantly attenuated kidney and liver injury after P as well as P/D.
PRE consisting of 10 min of P followed by 10 min of D decreases the oxidative stress induced by sustained P in the plasma, liver, and kidney. PRE significantly limits liver and kidney injury after prolonged P and P/D. After further studies to define its ideal timing, PRE before L incorporating P may have clinical relevance, especially for elderly patients or those with impaired hepatic and/or renal function or perfusion.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-002-9096-z</identifier><identifier>PMID: 12584602</identifier><identifier>CODEN: SUREEX</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Alanine Transaminase - analysis ; Alanine Transaminase - blood ; Animals ; Biological and medical sciences ; Carbon Dioxide - therapeutic use ; D-Alanine Transaminase ; Glutathione - metabolism ; Insufflation - adverse effects ; Insufflation - methods ; Ischemic Preconditioning - methods ; Kidney - blood supply ; Kidney - chemistry ; Kidney - injuries ; Laparoscopy - adverse effects ; Laparoscopy - methods ; Liver - blood supply ; Liver - chemistry ; Liver - injuries ; Male ; Malondialdehyde - analysis ; Malondialdehyde - blood ; Medical sciences ; Miscellaneous ; Oxidative Stress - physiology ; Pneumoperitoneum, Artificial - adverse effects ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury - etiology ; Reperfusion Injury - prevention & control ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><ispartof>Surgical endoscopy, 2003-05, Vol.17 (5), p.819-824</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-4fbf7edd77e0ab1b0fa10aab96774a37414ed6bf768ea9ac2c9508d4c23ba87c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14833329$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12584602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YILMAZ, S</creatorcontrib><creatorcontrib>KOKEN, T</creatorcontrib><creatorcontrib>TOKYOL, C</creatorcontrib><creatorcontrib>KAHRAMAN, A</creatorcontrib><creatorcontrib>AKBULUT, G</creatorcontrib><creatorcontrib>SERTESER, M</creatorcontrib><creatorcontrib>POLAT, C</creatorcontrib><creatorcontrib>GOKCE, C</creatorcontrib><creatorcontrib>GOKCE, O</creatorcontrib><title>Can preconditioning reduce laparoscopy-induced tissue injury?</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><description>Pneumoperitoneum (P) created to facilitate laparoscopy (L) is associated with splanchnic perfusion, ischemia/reperfusion (I/R) injury, and oxidative stress. In this randomized controlled experimental study with blind outcome assessment, we evaluated the effect of preconditioning (PRE) on L-induced I/R injury.
The subjects were 40 Sprague-Dawley male rats. P was created in all except controls, using carbondioxide (CO2) insufflation under a pressure of 15 mmHg. PRE consisted of 10 min of P, followed by 10 min of deflation (D). The rats were randomized to the following groups: Group P was subjected to 60 min of P. Group P/D was subjected to 60 min of P, followed by 45 min of D. Group PRE/P was subjected to PRE, followed by 60 min of P. Group PRE/P/D was subjected to PRE, followed by 60 min of P and 45 min of D. Group C (control) was subjected to a sham operation, without P. Its anesthesia time was equal to that for group PRE/P/D. At the end of the experiments, the rats were killed; blood, liver, and kidney samples were then obtained and coded. Plasma alanine aminotransferase (ALT) and malondialdehyde (MDA), as well as homogenized tissue MDA levels and glutathione (GSH) activities, were measured; tissue samples were assessed for histopathological evidence of injury; all assessments were done by investigators blinded to the study design. The results were decoded and analyzed statistically with the Kruskal-Wallis and Mann Whitney tests. A p <0.05 was considered significant.
Plasma ALT as well as plasma, liver, and kidney MDA levels and liver and kidney injury scores were increased, whereas liver and kidney GSH values were decreased in groups P and P/D, as compared to group C. Rats subjected to PRE before P had plasma ALT, kidney MDA, and kidney and liver GSH levels comparable to controls; their kidney and liver injury scores were higher than controls but significantly lower than nonpreconditioned animals. PRE enabled decreased plasma, kidney, and liver MDA as well as increased kidney GSH if applied before P; its efficacy on oxidative stress was limited to providing decreased kidney MDA and increased kidney GSH if applied before P/D. However, PRE significantly attenuated kidney and liver injury after P as well as P/D.
PRE consisting of 10 min of P followed by 10 min of D decreases the oxidative stress induced by sustained P in the plasma, liver, and kidney. PRE significantly limits liver and kidney injury after prolonged P and P/D. After further studies to define its ideal timing, PRE before L incorporating P may have clinical relevance, especially for elderly patients or those with impaired hepatic and/or renal function or perfusion.</description><subject>Alanine Transaminase - analysis</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide - therapeutic use</subject><subject>D-Alanine Transaminase</subject><subject>Glutathione - metabolism</subject><subject>Insufflation - adverse effects</subject><subject>Insufflation - methods</subject><subject>Ischemic Preconditioning - methods</subject><subject>Kidney - blood supply</subject><subject>Kidney - chemistry</subject><subject>Kidney - injuries</subject><subject>Laparoscopy - adverse effects</subject><subject>Laparoscopy - methods</subject><subject>Liver - blood supply</subject><subject>Liver - chemistry</subject><subject>Liver - injuries</subject><subject>Male</subject><subject>Malondialdehyde - analysis</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Oxidative Stress - physiology</subject><subject>Pneumoperitoneum, Artificial - adverse effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reperfusion Injury - etiology</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkE1LxDAQhoMoun78AC9SBL1FJx9tmoOILH6B4EXPYZqmkqWb1mR7WH-9WXZB8DQwPO_LzEPIOYMbBqBuE4CsJAXgVIOu6M8emTEpOOWc1ftkBloA5UrLI3Kc0gIyrll5SI4YL2tZAZ-RuzmGYozODqH1Kz8EH76K6NrJuqLHEeOQ7DCuqQ-bVVusfEqTK3xYTHF9f0oOOuyTO9vNE_L59Pgxf6Fv78-v84c3akUpV1R2Tadc2yrlABvWQIcMEBtdKSVRKMmka6vMVLVDjZZbXULdSstFg7Wy4oRcb3vHOHxPLq3M0ifr-h6DG6ZklOCVrCXL4OU_cDFMMeTbDGda5p_LOkNsC9n8XYquM2P0S4xrw8BsxJqtWJPFmo1Y85MzF7viqVm69i-xM5mBqx2AyWLfRQzWpz9O1kIIrsUvMsqBLQ</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>YILMAZ, S</creator><creator>KOKEN, T</creator><creator>TOKYOL, C</creator><creator>KAHRAMAN, A</creator><creator>AKBULUT, G</creator><creator>SERTESER, M</creator><creator>POLAT, C</creator><creator>GOKCE, C</creator><creator>GOKCE, O</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Can preconditioning reduce laparoscopy-induced tissue injury?</title><author>YILMAZ, S ; KOKEN, T ; TOKYOL, C ; KAHRAMAN, A ; AKBULUT, G ; SERTESER, M ; POLAT, C ; GOKCE, C ; GOKCE, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-4fbf7edd77e0ab1b0fa10aab96774a37414ed6bf768ea9ac2c9508d4c23ba87c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Alanine Transaminase - analysis</topic><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide - therapeutic use</topic><topic>D-Alanine Transaminase</topic><topic>Glutathione - metabolism</topic><topic>Insufflation - adverse effects</topic><topic>Insufflation - methods</topic><topic>Ischemic Preconditioning - methods</topic><topic>Kidney - blood supply</topic><topic>Kidney - chemistry</topic><topic>Kidney - injuries</topic><topic>Laparoscopy - adverse effects</topic><topic>Laparoscopy - methods</topic><topic>Liver - blood supply</topic><topic>Liver - chemistry</topic><topic>Liver - injuries</topic><topic>Male</topic><topic>Malondialdehyde - analysis</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Oxidative Stress - physiology</topic><topic>Pneumoperitoneum, Artificial - adverse effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reperfusion Injury - etiology</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YILMAZ, S</creatorcontrib><creatorcontrib>KOKEN, T</creatorcontrib><creatorcontrib>TOKYOL, C</creatorcontrib><creatorcontrib>KAHRAMAN, A</creatorcontrib><creatorcontrib>AKBULUT, G</creatorcontrib><creatorcontrib>SERTESER, M</creatorcontrib><creatorcontrib>POLAT, C</creatorcontrib><creatorcontrib>GOKCE, C</creatorcontrib><creatorcontrib>GOKCE, O</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YILMAZ, S</au><au>KOKEN, T</au><au>TOKYOL, C</au><au>KAHRAMAN, A</au><au>AKBULUT, G</au><au>SERTESER, M</au><au>POLAT, C</au><au>GOKCE, C</au><au>GOKCE, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can preconditioning reduce laparoscopy-induced tissue injury?</atitle><jtitle>Surgical endoscopy</jtitle><addtitle>Surg Endosc</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>17</volume><issue>5</issue><spage>819</spage><epage>824</epage><pages>819-824</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><coden>SUREEX</coden><abstract>Pneumoperitoneum (P) created to facilitate laparoscopy (L) is associated with splanchnic perfusion, ischemia/reperfusion (I/R) injury, and oxidative stress. In this randomized controlled experimental study with blind outcome assessment, we evaluated the effect of preconditioning (PRE) on L-induced I/R injury.
The subjects were 40 Sprague-Dawley male rats. P was created in all except controls, using carbondioxide (CO2) insufflation under a pressure of 15 mmHg. PRE consisted of 10 min of P, followed by 10 min of deflation (D). The rats were randomized to the following groups: Group P was subjected to 60 min of P. Group P/D was subjected to 60 min of P, followed by 45 min of D. Group PRE/P was subjected to PRE, followed by 60 min of P. Group PRE/P/D was subjected to PRE, followed by 60 min of P and 45 min of D. Group C (control) was subjected to a sham operation, without P. Its anesthesia time was equal to that for group PRE/P/D. At the end of the experiments, the rats were killed; blood, liver, and kidney samples were then obtained and coded. Plasma alanine aminotransferase (ALT) and malondialdehyde (MDA), as well as homogenized tissue MDA levels and glutathione (GSH) activities, were measured; tissue samples were assessed for histopathological evidence of injury; all assessments were done by investigators blinded to the study design. The results were decoded and analyzed statistically with the Kruskal-Wallis and Mann Whitney tests. A p <0.05 was considered significant.
Plasma ALT as well as plasma, liver, and kidney MDA levels and liver and kidney injury scores were increased, whereas liver and kidney GSH values were decreased in groups P and P/D, as compared to group C. Rats subjected to PRE before P had plasma ALT, kidney MDA, and kidney and liver GSH levels comparable to controls; their kidney and liver injury scores were higher than controls but significantly lower than nonpreconditioned animals. PRE enabled decreased plasma, kidney, and liver MDA as well as increased kidney GSH if applied before P; its efficacy on oxidative stress was limited to providing decreased kidney MDA and increased kidney GSH if applied before P/D. However, PRE significantly attenuated kidney and liver injury after P as well as P/D.
PRE consisting of 10 min of P followed by 10 min of D decreases the oxidative stress induced by sustained P in the plasma, liver, and kidney. PRE significantly limits liver and kidney injury after prolonged P and P/D. After further studies to define its ideal timing, PRE before L incorporating P may have clinical relevance, especially for elderly patients or those with impaired hepatic and/or renal function or perfusion.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>12584602</pmid><doi>10.1007/s00464-002-9096-z</doi><tpages>6</tpages></addata></record> |
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| subjects | Alanine Transaminase - analysis Alanine Transaminase - blood Animals Biological and medical sciences Carbon Dioxide - therapeutic use D-Alanine Transaminase Glutathione - metabolism Insufflation - adverse effects Insufflation - methods Ischemic Preconditioning - methods Kidney - blood supply Kidney - chemistry Kidney - injuries Laparoscopy - adverse effects Laparoscopy - methods Liver - blood supply Liver - chemistry Liver - injuries Male Malondialdehyde - analysis Malondialdehyde - blood Medical sciences Miscellaneous Oxidative Stress - physiology Pneumoperitoneum, Artificial - adverse effects Rats Rats, Sprague-Dawley Reperfusion Injury - etiology Reperfusion Injury - prevention & control Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases |
| title | Can preconditioning reduce laparoscopy-induced tissue injury? |
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