Processing of global, but not local, motion direction is deficient in schizophrenia
Visual motion processing is compromised in a substantial proportion of schizophrenic patients, but precise neural mechanisms underlying the motion-processing deficit have not yet been elaborated. The visual motion pathway includes a local and a global processing stage, each of which has distinct neu...
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| Veröffentlicht in: | Schizophrenia research 2003-06, Vol.61 (2), p.215-227 |
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| creator | Chen, Y. Nakayama, K. Levy, D. Matthysse, S. Holzman, P. |
| description | Visual motion processing is compromised in a substantial proportion of schizophrenic patients, but precise neural mechanisms underlying the motion-processing deficit have not yet been elaborated. The visual motion pathway includes a local and a global processing stage, each of which has distinct neural substrates. Here, we attempt to identify the stage(s) that are implicated in impaired motion processing of schizophrenia—local, global, or both. For schizophrenia patients (
n=23) and normal controls (
n=26), we measured (1) the thresholds for detecting the motion direction of a random dot pattern, a task that requires global motion processing, and (2) the thresholds for detecting the motion direction of a grating, a task that requires only local motion processing, using psychophysical methods. Schizophrenia patients showed elevated thresholds for detecting the direction of coherent motion, particularly for the high dot-density target. In contrast, schizophrenia patients showed normal thresholds for detecting the direction of motion of a grating. The results indicate that the global, but not the local, processing stage of the visual motion system is compromised in schizophrenia patients, thus implicating motion-sensitive brain areas that possess large receptive fields for spatial and temporal integration, such as Middle Temporal Area/Medial Superior Temporal Area. |
| doi_str_mv | 10.1016/S0920-9964(02)00222-0 |
| format | Article |
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n=23) and normal controls (
n=26), we measured (1) the thresholds for detecting the motion direction of a random dot pattern, a task that requires global motion processing, and (2) the thresholds for detecting the motion direction of a grating, a task that requires only local motion processing, using psychophysical methods. Schizophrenia patients showed elevated thresholds for detecting the direction of coherent motion, particularly for the high dot-density target. In contrast, schizophrenia patients showed normal thresholds for detecting the direction of motion of a grating. The results indicate that the global, but not the local, processing stage of the visual motion system is compromised in schizophrenia patients, thus implicating motion-sensitive brain areas that possess large receptive fields for spatial and temporal integration, such as Middle Temporal Area/Medial Superior Temporal Area.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/S0920-9964(02)00222-0</identifier><identifier>PMID: 12729873</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Attention ; Biological and medical sciences ; Coherent motion ; Female ; Field Dependence-Independence ; Humans ; Male ; Medical sciences ; Mental diseases ; Middle Aged ; Motion Perception ; Neuropsychological Tests ; Orientation ; Pattern Recognition, Visual ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychophysics ; Psychoses ; Pursuit, Smooth ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenic Psychology ; Sensory Thresholds ; Smooth pursuit ; Vision</subject><ispartof>Schizophrenia research, 2003-06, Vol.61 (2), p.215-227</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-372e0244a7c69aadb39ec2339bda9276913db3daf5eac4d9694f22fda0e5656c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0920-9964(02)00222-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14735690$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12729873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Y.</creatorcontrib><creatorcontrib>Nakayama, K.</creatorcontrib><creatorcontrib>Levy, D.</creatorcontrib><creatorcontrib>Matthysse, S.</creatorcontrib><creatorcontrib>Holzman, P.</creatorcontrib><title>Processing of global, but not local, motion direction is deficient in schizophrenia</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Visual motion processing is compromised in a substantial proportion of schizophrenic patients, but precise neural mechanisms underlying the motion-processing deficit have not yet been elaborated. The visual motion pathway includes a local and a global processing stage, each of which has distinct neural substrates. Here, we attempt to identify the stage(s) that are implicated in impaired motion processing of schizophrenia—local, global, or both. For schizophrenia patients (
n=23) and normal controls (
n=26), we measured (1) the thresholds for detecting the motion direction of a random dot pattern, a task that requires global motion processing, and (2) the thresholds for detecting the motion direction of a grating, a task that requires only local motion processing, using psychophysical methods. Schizophrenia patients showed elevated thresholds for detecting the direction of coherent motion, particularly for the high dot-density target. In contrast, schizophrenia patients showed normal thresholds for detecting the direction of motion of a grating. The results indicate that the global, but not the local, processing stage of the visual motion system is compromised in schizophrenia patients, thus implicating motion-sensitive brain areas that possess large receptive fields for spatial and temporal integration, such as Middle Temporal Area/Medial Superior Temporal Area.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Attention</subject><subject>Biological and medical sciences</subject><subject>Coherent motion</subject><subject>Female</subject><subject>Field Dependence-Independence</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental diseases</subject><subject>Middle Aged</subject><subject>Motion Perception</subject><subject>Neuropsychological Tests</subject><subject>Orientation</subject><subject>Pattern Recognition, Visual</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychophysics</subject><subject>Psychoses</subject><subject>Pursuit, Smooth</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenic Psychology</subject><subject>Sensory Thresholds</subject><subject>Smooth pursuit</subject><subject>Vision</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFqGzEQhkVoSBw3j5CiS0sL2XQk7UrWKRSTNgFDAm7PQivNJgrrlSOtA8nTd9c29bEnScP3z4w-Qi4YXDFg8vsSNIdCa1l-Bf4NgHNewBGZsEqJglegP5DJP-SUnOX8DACsAnVCThlXXM-UmJDlQ4oOcw7dI40NfWxjbdtLWm962sWettGNz1XsQ-yoDwnd9hYy9dgEF7Draehodk_hPa6fEnbBfiTHjW0znu_PKfnz8-b3_LZY3P-6m_9YFK4Us74QiiPwsrTKSW2tr4VGx4XQtbeaK6mZGGreNhVaV3otddlw3ngLWMlKOjElX3Z91ym-bDD3ZhWyw7a1HcZNNkpwyWbDN6ek2oEuxZwTNmadwsqmN8PAjDbN1qYZVRngZmvTwJD7tB-wqVfoD6m9vgH4vAdsHkQ1yXYu5ANXKlFJPTa63nE46HgNmEwe1TncGTU-hv-s8heG9pGY</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Chen, Y.</creator><creator>Nakayama, K.</creator><creator>Levy, D.</creator><creator>Matthysse, S.</creator><creator>Holzman, P.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>Processing of global, but not local, motion direction is deficient in schizophrenia</title><author>Chen, Y. ; Nakayama, K. ; Levy, D. ; Matthysse, S. ; Holzman, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-372e0244a7c69aadb39ec2339bda9276913db3daf5eac4d9694f22fda0e5656c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Attention</topic><topic>Biological and medical sciences</topic><topic>Coherent motion</topic><topic>Female</topic><topic>Field Dependence-Independence</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental diseases</topic><topic>Middle Aged</topic><topic>Motion Perception</topic><topic>Neuropsychological Tests</topic><topic>Orientation</topic><topic>Pattern Recognition, Visual</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychophysics</topic><topic>Psychoses</topic><topic>Pursuit, Smooth</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenic Psychology</topic><topic>Sensory Thresholds</topic><topic>Smooth pursuit</topic><topic>Vision</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Y.</creatorcontrib><creatorcontrib>Nakayama, K.</creatorcontrib><creatorcontrib>Levy, D.</creatorcontrib><creatorcontrib>Matthysse, S.</creatorcontrib><creatorcontrib>Holzman, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Y.</au><au>Nakayama, K.</au><au>Levy, D.</au><au>Matthysse, S.</au><au>Holzman, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Processing of global, but not local, motion direction is deficient in schizophrenia</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>61</volume><issue>2</issue><spage>215</spage><epage>227</epage><pages>215-227</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Visual motion processing is compromised in a substantial proportion of schizophrenic patients, but precise neural mechanisms underlying the motion-processing deficit have not yet been elaborated. The visual motion pathway includes a local and a global processing stage, each of which has distinct neural substrates. Here, we attempt to identify the stage(s) that are implicated in impaired motion processing of schizophrenia—local, global, or both. For schizophrenia patients (
n=23) and normal controls (
n=26), we measured (1) the thresholds for detecting the motion direction of a random dot pattern, a task that requires global motion processing, and (2) the thresholds for detecting the motion direction of a grating, a task that requires only local motion processing, using psychophysical methods. Schizophrenia patients showed elevated thresholds for detecting the direction of coherent motion, particularly for the high dot-density target. In contrast, schizophrenia patients showed normal thresholds for detecting the direction of motion of a grating. The results indicate that the global, but not the local, processing stage of the visual motion system is compromised in schizophrenia patients, thus implicating motion-sensitive brain areas that possess large receptive fields for spatial and temporal integration, such as Middle Temporal Area/Medial Superior Temporal Area.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12729873</pmid><doi>10.1016/S0920-9964(02)00222-0</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Attention Biological and medical sciences Coherent motion Female Field Dependence-Independence Humans Male Medical sciences Mental diseases Middle Aged Motion Perception Neuropsychological Tests Orientation Pattern Recognition, Visual Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychophysics Psychoses Pursuit, Smooth Schizophrenia Schizophrenia - diagnosis Schizophrenic Psychology Sensory Thresholds Smooth pursuit Vision |
| title | Processing of global, but not local, motion direction is deficient in schizophrenia |
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