Specificity of a Tumor Marker (CA54/61) and Its Individual Epitopes Recognized by Monoclonal Antibodies, MA54 and MA61, in Human Tumor Patients
The specificity of a tumor marker (CA54/61) and its individual epitopes (CA54 and CA61) recognized by monoclonal antibodies (MA54 and MA61) and expressed by the same tumor marker were studied. Serum levels of CA54 and CA61 were compared with that of CA54/61. In lung adenocarcinoma and ovarian carcin...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 1992, Vol.6 (4), p.225-231 |
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| creator | Mochizuki, Hiroshi Nagoya, Kimiko Yamauchi, Tadakazu Takao, Yoshimi Masuko, Hideyuki Sato, Hiroshi Sasaki, Hirosuke Itoh, Kotaro Tsukazaki, Katsumi Udagawa, Yasuhiro Kobayashi, Toshifumi Nozawa, Shiro |
| description | The specificity of a tumor marker (CA54/61) and its individual epitopes (CA54 and CA61) recognized by monoclonal antibodies (MA54 and MA61) and expressed by the same tumor marker were studied. Serum levels of CA54 and CA61 were compared with that of CA54/61. In lung adenocarcinoma and ovarian carcinoma, the positive rates of CA61 (42% and 68%) were higher than those of CA54 (32% and 32%) and similar to those of CA54/61 (45% and 74%). The serum levels of CA54 and CA61 showed a significant correlation (r=0.78), but 22% of tested sera were positive for CA54 and negative for CA61 or negative for CA54 and positive for CA61. It was demonstrated that the tumor specificity between CA54 and CA61 was not same and that the tumor specificity of CA54/61 was similar to that of CA61 rather than CA54. Moreover, the difference in the tumor specificity between CA54 and CA61 was considered to be reflected in the difference in their epitope structure. © 1992 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jcla.1860060411 |
| format | Article |
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Serum levels of CA54 and CA61 were compared with that of CA54/61. In lung adenocarcinoma and ovarian carcinoma, the positive rates of CA61 (42% and 68%) were higher than those of CA54 (32% and 32%) and similar to those of CA54/61 (45% and 74%). The serum levels of CA54 and CA61 showed a significant correlation (r=0.78), but 22% of tested sera were positive for CA54 and negative for CA61 or negative for CA54 and positive for CA61. It was demonstrated that the tumor specificity between CA54 and CA61 was not same and that the tumor specificity of CA54/61 was similar to that of CA61 rather than CA54. Moreover, the difference in the tumor specificity between CA54 and CA61 was considered to be reflected in the difference in their epitope structure. © 1992 Wiley‐Liss, Inc.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.1860060411</identifier><identifier>PMID: 1383482</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antibodies, Monoclonal ; Antibodies, Neoplasm ; Antigens, Tumor-Associated, Carbohydrate - blood ; Binding, Competitive ; Biomarkers, Tumor - blood ; enzyme immunoassay ; Epitopes - blood ; Female ; Genital Neoplasms, Female - immunology ; Humans ; lung carcinoma ; Lung Diseases - immunology ; Lung Neoplasms - immunology ; Neoplasms - immunology ; ovarian carcinoma ; Ovarian Neoplasms - immunology ; Pregnancy ; sialyl-Tn ; Tumor Cells, Cultured - immunology</subject><ispartof>Journal of clinical laboratory analysis, 1992, Vol.6 (4), p.225-231</ispartof><rights>Copyright © 1992 Wiley Periodicals, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4621-953cf5f28061b1c1f353dbbdb4eb59a64d1ac9f22ebb54fe4fce683e88d671d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcla.1860060411$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcla.1860060411$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1383482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mochizuki, Hiroshi</creatorcontrib><creatorcontrib>Nagoya, Kimiko</creatorcontrib><creatorcontrib>Yamauchi, Tadakazu</creatorcontrib><creatorcontrib>Takao, Yoshimi</creatorcontrib><creatorcontrib>Masuko, Hideyuki</creatorcontrib><creatorcontrib>Sato, Hiroshi</creatorcontrib><creatorcontrib>Sasaki, Hirosuke</creatorcontrib><creatorcontrib>Itoh, Kotaro</creatorcontrib><creatorcontrib>Tsukazaki, Katsumi</creatorcontrib><creatorcontrib>Udagawa, Yasuhiro</creatorcontrib><creatorcontrib>Kobayashi, Toshifumi</creatorcontrib><creatorcontrib>Nozawa, Shiro</creatorcontrib><title>Specificity of a Tumor Marker (CA54/61) and Its Individual Epitopes Recognized by Monoclonal Antibodies, MA54 and MA61, in Human Tumor Patients</title><title>Journal of clinical laboratory analysis</title><addtitle>J. Clin. Lab. Anal</addtitle><description>The specificity of a tumor marker (CA54/61) and its individual epitopes (CA54 and CA61) recognized by monoclonal antibodies (MA54 and MA61) and expressed by the same tumor marker were studied. Serum levels of CA54 and CA61 were compared with that of CA54/61. In lung adenocarcinoma and ovarian carcinoma, the positive rates of CA61 (42% and 68%) were higher than those of CA54 (32% and 32%) and similar to those of CA54/61 (45% and 74%). The serum levels of CA54 and CA61 showed a significant correlation (r=0.78), but 22% of tested sera were positive for CA54 and negative for CA61 or negative for CA54 and positive for CA61. It was demonstrated that the tumor specificity between CA54 and CA61 was not same and that the tumor specificity of CA54/61 was similar to that of CA61 rather than CA54. Moreover, the difference in the tumor specificity between CA54 and CA61 was considered to be reflected in the difference in their epitope structure. © 1992 Wiley‐Liss, Inc.</description><subject>Antibodies, Monoclonal</subject><subject>Antibodies, Neoplasm</subject><subject>Antigens, Tumor-Associated, Carbohydrate - blood</subject><subject>Binding, Competitive</subject><subject>Biomarkers, Tumor - blood</subject><subject>enzyme immunoassay</subject><subject>Epitopes - blood</subject><subject>Female</subject><subject>Genital Neoplasms, Female - immunology</subject><subject>Humans</subject><subject>lung carcinoma</subject><subject>Lung Diseases - immunology</subject><subject>Lung Neoplasms - immunology</subject><subject>Neoplasms - immunology</subject><subject>ovarian carcinoma</subject><subject>Ovarian Neoplasms - immunology</subject><subject>Pregnancy</subject><subject>sialyl-Tn</subject><subject>Tumor Cells, Cultured - immunology</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAURSMEKkNhzQrJKwRS0_GzY8cRqyjqtINmAEEREhvL8QdyycQhToDhT_CXyZARFauu3uLee97iJMlTwOeAMVne6Eadg-AYc5wB3EsWgAuREkHY_WSBhchTgYE-TB7FeIMxFgXwk-QEqKCZIIvk94fOau-89sMeBYcUuh53oUdb1X-1PXpRlSxbcniJVGvQeoho3Rr_3ZtRNeii80PobETvrQ5fWv_LGlTv0Ta0QTehnRplO_g6GG_jGdpOpL-UbcnhDPkWXY071R7_vVODt-0QHycPnGqifXK8p8nH1cV1dZVu3l6uq3KT6owTSAtGtWOOCMyhBg2OMmrq2tSZrVmheGZA6cIRYuuaZc5mTlsuqBXC8BxMQU-T5zO368O30cZB7nzUtmlUa8MYZU4JhxyzO4vAGaEEDsTlXNR9iLG3Tna936l-LwHLgyt5cCVvXU2LZ0f0WO-sue3Pcqb81Zz_8I3d34WTr6tN-R89ndc-Dvbnv_XkVfKc5kx-enMpabUSK7ZZyc_0DzA7rq0</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Mochizuki, Hiroshi</creator><creator>Nagoya, Kimiko</creator><creator>Yamauchi, Tadakazu</creator><creator>Takao, Yoshimi</creator><creator>Masuko, Hideyuki</creator><creator>Sato, Hiroshi</creator><creator>Sasaki, Hirosuke</creator><creator>Itoh, Kotaro</creator><creator>Tsukazaki, Katsumi</creator><creator>Udagawa, Yasuhiro</creator><creator>Kobayashi, Toshifumi</creator><creator>Nozawa, Shiro</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Specificity of a Tumor Marker (CA54/61) and Its Individual Epitopes Recognized by Monoclonal Antibodies, MA54 and MA61, in Human Tumor Patients</title><author>Mochizuki, Hiroshi ; Nagoya, Kimiko ; Yamauchi, Tadakazu ; Takao, Yoshimi ; Masuko, Hideyuki ; Sato, Hiroshi ; Sasaki, Hirosuke ; Itoh, Kotaro ; Tsukazaki, Katsumi ; Udagawa, Yasuhiro ; Kobayashi, Toshifumi ; Nozawa, Shiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4621-953cf5f28061b1c1f353dbbdb4eb59a64d1ac9f22ebb54fe4fce683e88d671d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Antibodies, Monoclonal</topic><topic>Antibodies, Neoplasm</topic><topic>Antigens, Tumor-Associated, Carbohydrate - blood</topic><topic>Binding, Competitive</topic><topic>Biomarkers, Tumor - blood</topic><topic>enzyme immunoassay</topic><topic>Epitopes - blood</topic><topic>Female</topic><topic>Genital Neoplasms, Female - immunology</topic><topic>Humans</topic><topic>lung carcinoma</topic><topic>Lung Diseases - immunology</topic><topic>Lung Neoplasms - immunology</topic><topic>Neoplasms - immunology</topic><topic>ovarian carcinoma</topic><topic>Ovarian Neoplasms - immunology</topic><topic>Pregnancy</topic><topic>sialyl-Tn</topic><topic>Tumor Cells, Cultured - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mochizuki, Hiroshi</creatorcontrib><creatorcontrib>Nagoya, Kimiko</creatorcontrib><creatorcontrib>Yamauchi, Tadakazu</creatorcontrib><creatorcontrib>Takao, Yoshimi</creatorcontrib><creatorcontrib>Masuko, Hideyuki</creatorcontrib><creatorcontrib>Sato, Hiroshi</creatorcontrib><creatorcontrib>Sasaki, Hirosuke</creatorcontrib><creatorcontrib>Itoh, Kotaro</creatorcontrib><creatorcontrib>Tsukazaki, Katsumi</creatorcontrib><creatorcontrib>Udagawa, Yasuhiro</creatorcontrib><creatorcontrib>Kobayashi, Toshifumi</creatorcontrib><creatorcontrib>Nozawa, Shiro</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mochizuki, Hiroshi</au><au>Nagoya, Kimiko</au><au>Yamauchi, Tadakazu</au><au>Takao, Yoshimi</au><au>Masuko, Hideyuki</au><au>Sato, Hiroshi</au><au>Sasaki, Hirosuke</au><au>Itoh, Kotaro</au><au>Tsukazaki, Katsumi</au><au>Udagawa, Yasuhiro</au><au>Kobayashi, Toshifumi</au><au>Nozawa, Shiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specificity of a Tumor Marker (CA54/61) and Its Individual Epitopes Recognized by Monoclonal Antibodies, MA54 and MA61, in Human Tumor Patients</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J. Clin. Lab. Anal</addtitle><date>1992</date><risdate>1992</risdate><volume>6</volume><issue>4</issue><spage>225</spage><epage>231</epage><pages>225-231</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>The specificity of a tumor marker (CA54/61) and its individual epitopes (CA54 and CA61) recognized by monoclonal antibodies (MA54 and MA61) and expressed by the same tumor marker were studied. Serum levels of CA54 and CA61 were compared with that of CA54/61. In lung adenocarcinoma and ovarian carcinoma, the positive rates of CA61 (42% and 68%) were higher than those of CA54 (32% and 32%) and similar to those of CA54/61 (45% and 74%). The serum levels of CA54 and CA61 showed a significant correlation (r=0.78), but 22% of tested sera were positive for CA54 and negative for CA61 or negative for CA54 and positive for CA61. It was demonstrated that the tumor specificity between CA54 and CA61 was not same and that the tumor specificity of CA54/61 was similar to that of CA61 rather than CA54. Moreover, the difference in the tumor specificity between CA54 and CA61 was considered to be reflected in the difference in their epitope structure. © 1992 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1383482</pmid><doi>10.1002/jcla.1860060411</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0887-8013 |
| ispartof | Journal of clinical laboratory analysis, 1992, Vol.6 (4), p.225-231 |
| issn | 0887-8013 1098-2825 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Antibodies, Monoclonal Antibodies, Neoplasm Antigens, Tumor-Associated, Carbohydrate - blood Binding, Competitive Biomarkers, Tumor - blood enzyme immunoassay Epitopes - blood Female Genital Neoplasms, Female - immunology Humans lung carcinoma Lung Diseases - immunology Lung Neoplasms - immunology Neoplasms - immunology ovarian carcinoma Ovarian Neoplasms - immunology Pregnancy sialyl-Tn Tumor Cells, Cultured - immunology |
| title | Specificity of a Tumor Marker (CA54/61) and Its Individual Epitopes Recognized by Monoclonal Antibodies, MA54 and MA61, in Human Tumor Patients |
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