Targeted prodrug treatment of HER-2-positive breast tumor cells using trastuzumab and paclitaxel linked by A-Z-CINN Linker

Targeting drugs for delivery and release has the potential to increase the efficacy of treatment. A bifunctional linker, A-Z-CINN Linker was used to create a targeted prodrug, A-Z-CINN 310. A-Z-CINN Linker links to a potent chemotherapeutic agent, paclitaxel, via an energy-reversible ester bond and...

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Veröffentlicht in:	Journal of experimental therapeutics & oncology 2003-01, Vol.3 (1), p.27-35
Hauptverfasser:	Gilbert, Carl W, McGowan, Eleanor B, Seery, Gerald B, Black, Kirby S, Pegram, Mark D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic Agents - chemical synthesis Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Breast Neoplasms - drug therapy Breast Neoplasms - genetics Chromatography, High Pressure Liquid Drug Delivery Systems Female Genes, erbB-2 Hydrolysis Immunoconjugates - chemistry Immunoconjugates - therapeutic use Light Mice Mice, SCID Paclitaxel - administration & dosage Paclitaxel - analogs & derivatives Paclitaxel - chemistry Paclitaxel - pharmacology Paclitaxel - therapeutic use Prodrugs - chemical synthesis Prodrugs - therapeutic use Receptor, ErbB-2 - drug effects Time Factors Trastuzumab Xenograft Model Antitumor Assays
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