Synthesis and use of a pseudo-cysteine for native chemical ligation

The process of native chemical ligation (NCL) is well described in the literature. An N‐terminal cysteine‐containing peptide reacts with a C‐terminal thioester‐containing peptide to yield a native amide bond after transesterification and acyl transfer. An N‐terminal cysteine is required as both the...

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Veröffentlicht in:	Journal of peptide science 2003-04, Vol.9 (4), p.221-228
Hauptverfasser:	Alves, David A., Esser, Dirk, Broadbridge, Robert J., Beevers, Andrew P. G., Chapman, Christopher P., Winsor, Clare E., Betley, Jason R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cysteine - analogs & derivatives Cysteine - chemical synthesis Green Fluorescent Proteins intein Luminescent Proteins - chemistry native chemical ligation Peptides - chemical synthesis pseudo-cysteine reactive scaffold
Online-Zugang:	Volltext
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