Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy

Since neural progenitor cells can engraft stably into brain tumors and differentiate along the neuronal and glial line, we tested the hypothesis that transplanted cytosine deaminase (CD)-expressing ST14A cells (an immortalized neural progenitor cell line) can convert locally 5-fluorocytosine (5-FC)...

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Veröffentlicht in:	Cancer gene therapy 2003-05, Vol.10 (5), p.396-402
Hauptverfasser:	Barresi, Vincenza, Belluardo, Natale, Sipione, Simonetta, Mudó, Giuseppa, Cattaneo, Elena, Condorelli, Daniele Filippo
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Animals Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - enzymology Brain Neoplasms - pathology Brain tumors Cancer therapies Care and treatment Cells Cells, Cultured Cytosine Cytosine deaminase Cytosine Deaminase - genetics Cytosine Deaminase - metabolism Escherichia coli - enzymology Flucytosine - metabolism Fluorouracil - metabolism Gene Expression Gene Therapy Genetic Therapy Glioma Glioma - drug therapy Glioma - enzymology Glioma - pathology Glioma cells Health aspects Neural stem cells Neuronal-glial interactions Neurons - cytology original-article Prodrugs Prodrugs - metabolism Progenitor cells Rats Rats, Sprague-Dawley Stem Cell Transplantation Stem Cells - enzymology Transfection Transplantation Tumors
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