Anti-HIV-1 activity of enfuvirtide (T-20) by inhibition of bystander cell death

Infection by human immunodeficiency virus type 1 (HIV-1) has been associated with increased cell death of both infected and bystander cells. The envelope glycoprotein complex appears to play an active role in HIV-induced death of bystander cells. We quantified cell-to-cell fusion, single cell death...

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Veröffentlicht in:	Antiviral therapy 2003-04, Vol.8 (2), p.155-161
Hauptverfasser:	BARRETINA, Jordi, BLANCO, Julia, ARMAND-UGON, Mercedes, GUTIERREZ, Arantxa, CLOTET, Bonaventura, ESTE, José A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - pathology Cell Death - drug effects Cells, Cultured Coculture Techniques Dose-Response Relationship, Drug Giant Cells - drug effects HIV Envelope Protein gp41 - metabolism HIV Envelope Protein gp41 - pharmacology HIV-1 - drug effects HIV-1 - pathogenicity Humans Medical sciences Peptide Fragments - pharmacology Pharmacology. Drug treatments Virulence - drug effects Virus Replication - drug effects
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