6-Substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists

We have prepared a series of 6-substituted decahydroisoquinoline-3-carboxylic acids, and structurally similar analogs, as potential N-methyl-D-aspartate receptor antagonists. There is a large body of evidence to support the use of such compounds as cerebroprotective agents in a variety of acute and...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-09, Vol.35 (19), p.3547-3560
Hauptverfasser:	Ornstein, Paul L, Schoepp, Darryle D, Arnold, M. Brian, Augenstein, Nancy K, Lodge, David, Millar, John D, Chambers, John, Campbell, Jack, Paschal, Jonathan W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Binding, Competitive Brain - drug effects Brain - metabolism Carboxylic Acids - chemical synthesis Carboxylic Acids - chemistry Carboxylic Acids - pharmacology Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Isoquinolines - chemical synthesis Isoquinolines - chemistry Isoquinolines - pharmacology Mice Molecular Conformation Organic chemistry Preparations and properties Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Stereoisomerism Structure-Activity Relationship
Online-Zugang:	Volltext
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