Screening of Substrate Analogs as Potential Enzyme Inhibitors for the Arginine Kinase of Trypanosoma cruzi

Arginine kinase catalyzes the transphosphorylation between phosphoarginine and ADP. Phosphoarginine is involved in temporal ATP buffering and inorganic phosphate regulation. Trypanosoma cruzi arginine kinase phosphorylates only l-arginine (specific activity 398.9 · mUE·min–1 · mg–1), and is inhibite...

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Veröffentlicht in:	The Journal of eukaryotic microbiology 2003-03, Vol.50 (2), p.132-134
Hauptverfasser:	PEREIRA, CLAUDIO A, ALONSO, GUILLERMO D, IVALDI, SOLEDAD, BOUVIER, LEÓN A, TORRES, HÉCTOR N, FLAWIÁ, MIRTHA M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - analogs & derivatives Arginine - metabolism Arginine - pharmacology Arginine Kinase - antagonists & inhibitors Biological and medical sciences Canavanine Canavanine - pharmacology Culture Media Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Guanidines - metabolism guanidino kinase homoarginine Homoarginine - pharmacology Life cycle. Host-agent relationship. Pathogenesis phosphagen kinase phosphoarginine Phosphorylation Phosphotransferases - metabolism Protozoa Trypanosoma cruzi - drug effects Trypanosoma cruzi - enzymology Trypanosoma cruzi - growth & development
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