Remission rates in breast cancer treated with preoperative chemotherapy and radiotherapy
Evaluation of remission rates after neoadjuvant chemotherapy alone or followed by preoperative radiotherapy. 194 women with 198 biopsy-proven breast tumors were evaluated in this retrospective study. Of the 198 cases evaluated, 64 received neoadjuvant chemotherapy followed by surgery and adjuvant ir...
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| Veröffentlicht in: | Strahlentherapie und Onkologie 2003-05, Vol.179 (5), p.306-311 |
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| creator | GERLACH, Bärbel AUDRETSCH, Werner GOGOLIN, Frank KÖNIGSHAUSEN, Theodor ROHN, Ralf SCHMITT, Gerd DIMMERLING, Peter GRIPP, Stephan HARTMANN, Karl Axel |
| description | Evaluation of remission rates after neoadjuvant chemotherapy alone or followed by preoperative radiotherapy.
194 women with 198 biopsy-proven breast tumors were evaluated in this retrospective study. Of the 198 cases evaluated, 64 received neoadjuvant chemotherapy followed by surgery and adjuvant irradiation (CT group). In 134 cases, sequential preoperative chemo-/radiotherapy (CT-RT group) was given. In both groups, endocrine treatment was initiated in case of positive hormone receptor status after chemotherapy. The whole breast was homogeneously irradiated using 2-Gy fractions up to a total dose of 50 Gy, followed by a boost of 6-11 Gy to the tumor.
A histologically proven complete remission (pCR) was achieved in 3% (2/64) in the CT and in 42% (56/134) in the CTRT group. The logistic regression analysis, including clinical tumor category (cT), lymph node (cN) and metastasis status (cM), grading (G), hormone receptor status (HRS), number of preoperative chemotherapy cycles, preoperative tumor volume, and preoperative radiotherapy, revealed that HRS (p = 0.0232) and radiotherapy (p < 0.0001) were significant factors for achieving pCR.
Combination of neoadjuvant chemo-/radiotherapy results in significantly higher rates of complete remission than neoadjuvant chemotherapy alone. The significance for tumor-free and overall survival has to be evaluated. |
| doi_str_mv | 10.1007/s00066-003-1019-y |
| format | Article |
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194 women with 198 biopsy-proven breast tumors were evaluated in this retrospective study. Of the 198 cases evaluated, 64 received neoadjuvant chemotherapy followed by surgery and adjuvant irradiation (CT group). In 134 cases, sequential preoperative chemo-/radiotherapy (CT-RT group) was given. In both groups, endocrine treatment was initiated in case of positive hormone receptor status after chemotherapy. The whole breast was homogeneously irradiated using 2-Gy fractions up to a total dose of 50 Gy, followed by a boost of 6-11 Gy to the tumor.
A histologically proven complete remission (pCR) was achieved in 3% (2/64) in the CT and in 42% (56/134) in the CTRT group. The logistic regression analysis, including clinical tumor category (cT), lymph node (cN) and metastasis status (cM), grading (G), hormone receptor status (HRS), number of preoperative chemotherapy cycles, preoperative tumor volume, and preoperative radiotherapy, revealed that HRS (p = 0.0232) and radiotherapy (p < 0.0001) were significant factors for achieving pCR.
Combination of neoadjuvant chemo-/radiotherapy results in significantly higher rates of complete remission than neoadjuvant chemotherapy alone. The significance for tumor-free and overall survival has to be evaluated.</description><identifier>ISSN: 0179-7158</identifier><identifier>EISSN: 1439-099X</identifier><identifier>DOI: 10.1007/s00066-003-1019-y</identifier><identifier>PMID: 12740657</identifier><identifier>CODEN: STONE4</identifier><language>eng</language><publisher>München: Springer</publisher><subject>Adult ; Aged ; Antineoplastic agents ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Breast - pathology ; Breast Neoplasms - drug therapy ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Breast Neoplasms - radiotherapy ; Breast Neoplasms - surgery ; Breast Neoplasms - therapy ; Chemotherapy, Adjuvant ; Cobalt Radioisotopes - therapeutic use ; Combined Modality Therapy ; Combined treatments (chemotherapy of immunotherapy associated with an other treatment) ; Disease-Free Survival ; Female ; Humans ; Logistic Models ; Mastectomy, Modified Radical ; Mastectomy, Segmental ; Medical sciences ; Middle Aged ; Neoadjuvant Therapy ; Pharmacology. Drug treatments ; Preoperative Care ; Radiotherapy Dosage ; Remission Induction ; Retrospective Studies ; Time Factors</subject><ispartof>Strahlentherapie und Onkologie, 2003-05, Vol.179 (5), p.306-311</ispartof><rights>2003 INIST-CNRS</rights><rights>Urban & Vogel München 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-5c5b206093b2391af759f792285234e2afb4a4ee62c00521a354a251a0f9b1023</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14775215$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12740657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GERLACH, Bärbel</creatorcontrib><creatorcontrib>AUDRETSCH, Werner</creatorcontrib><creatorcontrib>GOGOLIN, Frank</creatorcontrib><creatorcontrib>KÖNIGSHAUSEN, Theodor</creatorcontrib><creatorcontrib>ROHN, Ralf</creatorcontrib><creatorcontrib>SCHMITT, Gerd</creatorcontrib><creatorcontrib>DIMMERLING, Peter</creatorcontrib><creatorcontrib>GRIPP, Stephan</creatorcontrib><creatorcontrib>HARTMANN, Karl Axel</creatorcontrib><title>Remission rates in breast cancer treated with preoperative chemotherapy and radiotherapy</title><title>Strahlentherapie und Onkologie</title><addtitle>Strahlenther Onkol</addtitle><description>Evaluation of remission rates after neoadjuvant chemotherapy alone or followed by preoperative radiotherapy.
194 women with 198 biopsy-proven breast tumors were evaluated in this retrospective study. Of the 198 cases evaluated, 64 received neoadjuvant chemotherapy followed by surgery and adjuvant irradiation (CT group). In 134 cases, sequential preoperative chemo-/radiotherapy (CT-RT group) was given. In both groups, endocrine treatment was initiated in case of positive hormone receptor status after chemotherapy. The whole breast was homogeneously irradiated using 2-Gy fractions up to a total dose of 50 Gy, followed by a boost of 6-11 Gy to the tumor.
A histologically proven complete remission (pCR) was achieved in 3% (2/64) in the CT and in 42% (56/134) in the CTRT group. The logistic regression analysis, including clinical tumor category (cT), lymph node (cN) and metastasis status (cM), grading (G), hormone receptor status (HRS), number of preoperative chemotherapy cycles, preoperative tumor volume, and preoperative radiotherapy, revealed that HRS (p = 0.0232) and radiotherapy (p < 0.0001) were significant factors for achieving pCR.
Combination of neoadjuvant chemo-/radiotherapy results in significantly higher rates of complete remission than neoadjuvant chemotherapy alone. The significance for tumor-free and overall survival has to be evaluated.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Breast - pathology</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Breast Neoplasms - surgery</subject><subject>Breast Neoplasms - therapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Cobalt Radioisotopes - therapeutic use</subject><subject>Combined Modality Therapy</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Mastectomy, Modified Radical</subject><subject>Mastectomy, Segmental</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy</subject><subject>Pharmacology. 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194 women with 198 biopsy-proven breast tumors were evaluated in this retrospective study. Of the 198 cases evaluated, 64 received neoadjuvant chemotherapy followed by surgery and adjuvant irradiation (CT group). In 134 cases, sequential preoperative chemo-/radiotherapy (CT-RT group) was given. In both groups, endocrine treatment was initiated in case of positive hormone receptor status after chemotherapy. The whole breast was homogeneously irradiated using 2-Gy fractions up to a total dose of 50 Gy, followed by a boost of 6-11 Gy to the tumor.
A histologically proven complete remission (pCR) was achieved in 3% (2/64) in the CT and in 42% (56/134) in the CTRT group. The logistic regression analysis, including clinical tumor category (cT), lymph node (cN) and metastasis status (cM), grading (G), hormone receptor status (HRS), number of preoperative chemotherapy cycles, preoperative tumor volume, and preoperative radiotherapy, revealed that HRS (p = 0.0232) and radiotherapy (p < 0.0001) were significant factors for achieving pCR.
Combination of neoadjuvant chemo-/radiotherapy results in significantly higher rates of complete remission than neoadjuvant chemotherapy alone. The significance for tumor-free and overall survival has to be evaluated.</abstract><cop>München</cop><pub>Springer</pub><pmid>12740657</pmid><doi>10.1007/s00066-003-1019-y</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Breast - pathology Breast Neoplasms - drug therapy Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Breast Neoplasms - therapy Chemotherapy, Adjuvant Cobalt Radioisotopes - therapeutic use Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Disease-Free Survival Female Humans Logistic Models Mastectomy, Modified Radical Mastectomy, Segmental Medical sciences Middle Aged Neoadjuvant Therapy Pharmacology. Drug treatments Preoperative Care Radiotherapy Dosage Remission Induction Retrospective Studies Time Factors |
| title | Remission rates in breast cancer treated with preoperative chemotherapy and radiotherapy |
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