Histamine upregulates gene expression of endothelial nitric oxide synthase in human vascular endothelial cells

Histamine has a short-term, transient, stimulating effect on endothelial nitric oxide synthase (eNOS) activity; however, long-term effects on eNOS have not been described yet. In addition, the vascular effect of histamine seems to depend critically on eNOS functionality. Therefore, we studied the ef...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-05, Vol.107 (18), p.2348-2354
Hauptverfasser:	HUIGE LI, BURKHARDT, Christian, HEINRICH, Ulf-Rüdiger, BRAUSCH, Isolde, NING XIA, FÖRSTERRNANN, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood vessels and receptors Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Line Cells, Cultured Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - metabolism Enzyme Induction Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Histamine - pharmacology Humans Kinetics Nitric Oxide - biosynthesis Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III Oxidative Stress Promoter Regions, Genetic Protein Kinase Inhibitors Reactive Oxygen Species - metabolism Receptors, Histamine H1 - physiology RNA, Messenger - biosynthesis Transcriptional Activation Up-Regulation Vertebrates: cardiovascular system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!