Facile synthesis of [ 11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase

[ 11C]Edrophonium and its analogues have been synthesized for evaluation as new potential positron emission tomography (PET) imaging agents for heart acetylcholinesterase. The tracers were prepared by N-[ 11C]methylation of precursors using [ 11C]methyl triflate and isolated by solid-phase extractio...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-05, Vol.13 (10), p.1787-1790
Hauptverfasser:	Zheng, Qi-Huang, Liu, Xuan, Fei, Xiangshu, Wang, Ji-Quan, Mock, Bruce H., Glick-Wilson, Barbara E., Sullivan, Michael L., Hutchins, Gary D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carbon Radioisotopes Cholinesterase Inhibitors - chemical synthesis Contrast media. Radiopharmaceuticals Edrophonium - analogs & derivatives Edrophonium - chemical synthesis Equipment Design Heart - diagnostic imaging Humans Medical sciences Pharmacology. Drug treatments Radiopharmaceuticals - chemical synthesis Tomography, Emission-Computed - methods
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