Intraventricular Infusions of Anti‐Neural Cell Adhesion Molecules in a Discrete Posttraining Period Impair Consolidation of a Passive Avoidance Response in the Rat
: Intraventricular infusions of anti‐neural cell adhesion molecule (anti‐NCAM) are demonstrated to inhibit consolidation of a passive avoidance response when administered in the 6‐8‐h posttraining period. Anti‐NCAM was ineffective when administered during training or at any other time up to 10 h the...
Gespeichert in:
| Veröffentlicht in: | Journal of neurochemistry 1992-10, Vol.59 (4), p.1570-1573 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1573 |
|---|---|
| container_issue | 4 |
| container_start_page | 1570 |
| container_title | Journal of neurochemistry |
| container_volume | 59 |
| creator | Doyle, E. Nolan, P. M. Bell, R. Regan, C. M. |
| description | : Intraventricular infusions of anti‐neural cell adhesion molecule (anti‐NCAM) are demonstrated to inhibit consolidation of a passive avoidance response when administered in the 6‐8‐h posttraining period. Anti‐NCAM was ineffective when administered during training or at any other time up to 10 h thereafter, and no amnesic effects were observed with absorbed anti‐NCAM or anti‐neurofilament protein. Amnesia was observed only at the 48‐h recall time, and this could not be attributed to poor antibody penetration or a prolonged residence time, as studies with 125I‐labelled anti‐NCAM in trained animals demonstrated a rapid accumulation into all brain regions, and this was marked in the olfactory bulb and hippocampus, areas showing an inherent and paradigm‐specific increase in NCAM sialylation state, respectively. The lack of an amnesic action at the 24‐h recall time is attributed to anti‐NCAM‐impaired synapse structuring becoming apparent following the paradigm‐specific increases in NCAM sialylation state. |
| doi_str_mv | 10.1111/j.1471-4159.1992.tb08477.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73256270</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73256270</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3450-4a4d2da0c97db8c3a9373aa13e3a5d95d24d1525a96f0ed56be3ec884fbae4933</originalsourceid><addsrcrecordid>eNqVUcuO0zAUtRBoKAOfgGQhxC7BzzzYoCq8ioahQrC2buMbxlUaFzspMzs-gZ_gx_gSHLUalggvbNnnYR8fQp5wlvM0nm9zrkqeKa7rnNe1yMcNq1RZ5td3yOIWuksWjAmRSabEffIgxi1jvFAFPyNnXDFRs2JBfq2GMcAB0-zaqYdAV0M3ReeHSH1Hl8Pofv_4eYlTgJ422Pd0aa9wxukH32OSYKRuoEBfudgGHJGufRyTpxvc8JWuMThv6Wq3Bxdok2x97yyMs0HyB7qGGN0B6fLg0_nQIv2EcZ94ONuOV2kP40Nyr4M-4qPTek6-vHn9uXmXXXx8u2qWF1krlWaZAmWFBdbWpd1UrYRalhKAS5Sgba2tUJZroaEuOoZWFxuU2FaV6jaAqpbynDw7-u6D_zZhHM0upUqpYUA_RVNKoQtRsn8SeSFlpbRIxBdHYht8jAE7sw9uB-HGcGbmMs3WzI2ZuTEzl2lOZZrrJH58umXa7ND-lR7bS_jTEw6xhb4L6f9cvKVpLbVmc6qXR9p31-PNfzzAvL9suE5x_wBrlsAX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16338452</pqid></control><display><type>article</type><title>Intraventricular Infusions of Anti‐Neural Cell Adhesion Molecules in a Discrete Posttraining Period Impair Consolidation of a Passive Avoidance Response in the Rat</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Doyle, E. ; Nolan, P. M. ; Bell, R. ; Regan, C. M.</creator><creatorcontrib>Doyle, E. ; Nolan, P. M. ; Bell, R. ; Regan, C. M.</creatorcontrib><description>: Intraventricular infusions of anti‐neural cell adhesion molecule (anti‐NCAM) are demonstrated to inhibit consolidation of a passive avoidance response when administered in the 6‐8‐h posttraining period. Anti‐NCAM was ineffective when administered during training or at any other time up to 10 h thereafter, and no amnesic effects were observed with absorbed anti‐NCAM or anti‐neurofilament protein. Amnesia was observed only at the 48‐h recall time, and this could not be attributed to poor antibody penetration or a prolonged residence time, as studies with 125I‐labelled anti‐NCAM in trained animals demonstrated a rapid accumulation into all brain regions, and this was marked in the olfactory bulb and hippocampus, areas showing an inherent and paradigm‐specific increase in NCAM sialylation state, respectively. The lack of an amnesic action at the 24‐h recall time is attributed to anti‐NCAM‐impaired synapse structuring becoming apparent following the paradigm‐specific increases in NCAM sialylation state.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.1992.tb08477.x</identifier><identifier>PMID: 1402906</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amnesia - etiology ; Animals ; Antibodies - immunology ; Antibodies - physiology ; Anti‐neural cell adhesion molecules ; Avoidance Learning - physiology ; Biological and medical sciences ; Brain - metabolism ; Cell Adhesion Molecules, Neuronal - immunology ; Cell Adhesion Molecules, Neuronal - physiology ; Fundamental and applied biological sciences. Psychology ; Immunoglobulin G - immunology ; Immunoglobulin G - metabolism ; Immunologic Techniques ; Injections, Intraventricular ; Learning. Memory ; Memory consolidation ; Passive avoidance ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Wistar ; Time Factors ; Tissue Distribution</subject><ispartof>Journal of neurochemistry, 1992-10, Vol.59 (4), p.1570-1573</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3450-4a4d2da0c97db8c3a9373aa13e3a5d95d24d1525a96f0ed56be3ec884fbae4933</citedby><cites>FETCH-LOGICAL-c3450-4a4d2da0c97db8c3a9373aa13e3a5d95d24d1525a96f0ed56be3ec884fbae4933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.1992.tb08477.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.1992.tb08477.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5535503$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1402906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doyle, E.</creatorcontrib><creatorcontrib>Nolan, P. M.</creatorcontrib><creatorcontrib>Bell, R.</creatorcontrib><creatorcontrib>Regan, C. M.</creatorcontrib><title>Intraventricular Infusions of Anti‐Neural Cell Adhesion Molecules in a Discrete Posttraining Period Impair Consolidation of a Passive Avoidance Response in the Rat</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: Intraventricular infusions of anti‐neural cell adhesion molecule (anti‐NCAM) are demonstrated to inhibit consolidation of a passive avoidance response when administered in the 6‐8‐h posttraining period. Anti‐NCAM was ineffective when administered during training or at any other time up to 10 h thereafter, and no amnesic effects were observed with absorbed anti‐NCAM or anti‐neurofilament protein. Amnesia was observed only at the 48‐h recall time, and this could not be attributed to poor antibody penetration or a prolonged residence time, as studies with 125I‐labelled anti‐NCAM in trained animals demonstrated a rapid accumulation into all brain regions, and this was marked in the olfactory bulb and hippocampus, areas showing an inherent and paradigm‐specific increase in NCAM sialylation state, respectively. The lack of an amnesic action at the 24‐h recall time is attributed to anti‐NCAM‐impaired synapse structuring becoming apparent following the paradigm‐specific increases in NCAM sialylation state.</description><subject>Amnesia - etiology</subject><subject>Animals</subject><subject>Antibodies - immunology</subject><subject>Antibodies - physiology</subject><subject>Anti‐neural cell adhesion molecules</subject><subject>Avoidance Learning - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Cell Adhesion Molecules, Neuronal - immunology</subject><subject>Cell Adhesion Molecules, Neuronal - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin G - metabolism</subject><subject>Immunologic Techniques</subject><subject>Injections, Intraventricular</subject><subject>Learning. Memory</subject><subject>Memory consolidation</subject><subject>Passive avoidance</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><subject>Tissue Distribution</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUcuO0zAUtRBoKAOfgGQhxC7BzzzYoCq8ioahQrC2buMbxlUaFzspMzs-gZ_gx_gSHLUalggvbNnnYR8fQp5wlvM0nm9zrkqeKa7rnNe1yMcNq1RZ5td3yOIWuksWjAmRSabEffIgxi1jvFAFPyNnXDFRs2JBfq2GMcAB0-zaqYdAV0M3ReeHSH1Hl8Pofv_4eYlTgJ422Pd0aa9wxukH32OSYKRuoEBfudgGHJGufRyTpxvc8JWuMThv6Wq3Bxdok2x97yyMs0HyB7qGGN0B6fLg0_nQIv2EcZ94ONuOV2kP40Nyr4M-4qPTek6-vHn9uXmXXXx8u2qWF1krlWaZAmWFBdbWpd1UrYRalhKAS5Sgba2tUJZroaEuOoZWFxuU2FaV6jaAqpbynDw7-u6D_zZhHM0upUqpYUA_RVNKoQtRsn8SeSFlpbRIxBdHYht8jAE7sw9uB-HGcGbmMs3WzI2ZuTEzl2lOZZrrJH58umXa7ND-lR7bS_jTEw6xhb4L6f9cvKVpLbVmc6qXR9p31-PNfzzAvL9suE5x_wBrlsAX</recordid><startdate>199210</startdate><enddate>199210</enddate><creator>Doyle, E.</creator><creator>Nolan, P. M.</creator><creator>Bell, R.</creator><creator>Regan, C. M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>199210</creationdate><title>Intraventricular Infusions of Anti‐Neural Cell Adhesion Molecules in a Discrete Posttraining Period Impair Consolidation of a Passive Avoidance Response in the Rat</title><author>Doyle, E. ; Nolan, P. M. ; Bell, R. ; Regan, C. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3450-4a4d2da0c97db8c3a9373aa13e3a5d95d24d1525a96f0ed56be3ec884fbae4933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amnesia - etiology</topic><topic>Animals</topic><topic>Antibodies - immunology</topic><topic>Antibodies - physiology</topic><topic>Anti‐neural cell adhesion molecules</topic><topic>Avoidance Learning - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Cell Adhesion Molecules, Neuronal - immunology</topic><topic>Cell Adhesion Molecules, Neuronal - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin G - metabolism</topic><topic>Immunologic Techniques</topic><topic>Injections, Intraventricular</topic><topic>Learning. Memory</topic><topic>Memory consolidation</topic><topic>Passive avoidance</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doyle, E.</creatorcontrib><creatorcontrib>Nolan, P. M.</creatorcontrib><creatorcontrib>Bell, R.</creatorcontrib><creatorcontrib>Regan, C. M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doyle, E.</au><au>Nolan, P. M.</au><au>Bell, R.</au><au>Regan, C. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraventricular Infusions of Anti‐Neural Cell Adhesion Molecules in a Discrete Posttraining Period Impair Consolidation of a Passive Avoidance Response in the Rat</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1992-10</date><risdate>1992</risdate><volume>59</volume><issue>4</issue><spage>1570</spage><epage>1573</epage><pages>1570-1573</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: Intraventricular infusions of anti‐neural cell adhesion molecule (anti‐NCAM) are demonstrated to inhibit consolidation of a passive avoidance response when administered in the 6‐8‐h posttraining period. Anti‐NCAM was ineffective when administered during training or at any other time up to 10 h thereafter, and no amnesic effects were observed with absorbed anti‐NCAM or anti‐neurofilament protein. Amnesia was observed only at the 48‐h recall time, and this could not be attributed to poor antibody penetration or a prolonged residence time, as studies with 125I‐labelled anti‐NCAM in trained animals demonstrated a rapid accumulation into all brain regions, and this was marked in the olfactory bulb and hippocampus, areas showing an inherent and paradigm‐specific increase in NCAM sialylation state, respectively. The lack of an amnesic action at the 24‐h recall time is attributed to anti‐NCAM‐impaired synapse structuring becoming apparent following the paradigm‐specific increases in NCAM sialylation state.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1402906</pmid><doi>10.1111/j.1471-4159.1992.tb08477.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3042 |
| ispartof | Journal of neurochemistry, 1992-10, Vol.59 (4), p.1570-1573 |
| issn | 0022-3042 1471-4159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73256270 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amnesia - etiology Animals Antibodies - immunology Antibodies - physiology Anti‐neural cell adhesion molecules Avoidance Learning - physiology Biological and medical sciences Brain - metabolism Cell Adhesion Molecules, Neuronal - immunology Cell Adhesion Molecules, Neuronal - physiology Fundamental and applied biological sciences. Psychology Immunoglobulin G - immunology Immunoglobulin G - metabolism Immunologic Techniques Injections, Intraventricular Learning. Memory Memory consolidation Passive avoidance Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Time Factors Tissue Distribution |
| title | Intraventricular Infusions of Anti‐Neural Cell Adhesion Molecules in a Discrete Posttraining Period Impair Consolidation of a Passive Avoidance Response in the Rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T00%3A58%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intraventricular%20Infusions%20of%20Anti%E2%80%90Neural%20Cell%20Adhesion%20Molecules%20in%20a%20Discrete%20Posttraining%20Period%20Impair%20Consolidation%20of%20a%20Passive%20Avoidance%20Response%20in%20the%20Rat&rft.jtitle=Journal%20of%20neurochemistry&rft.au=Doyle,%20E.&rft.date=1992-10&rft.volume=59&rft.issue=4&rft.spage=1570&rft.epage=1573&rft.pages=1570-1573&rft.issn=0022-3042&rft.eissn=1471-4159&rft.coden=JONRA9&rft_id=info:doi/10.1111/j.1471-4159.1992.tb08477.x&rft_dat=%3Cproquest_cross%3E73256270%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16338452&rft_id=info:pmid/1402906&rfr_iscdi=true |