Tolerance, DCs and tryptophan: much ado about IDO

Indoleamine 2,3-dioxygenase (IDO) degrades the indole moiety of tryptophan, serotonin and melatonin, and initiates the production of neuroactive and immunoregulatory metabolites, collectively known as kynurenines. By locally depleting tryptophan and increasing proapoptotic kynurenines, IDO expressed...

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Veröffentlicht in:	Trends in immunology 2003-05, Vol.24 (5), p.242-248
Hauptverfasser:	Grohmann, Ursula, Fallarino, Francesca, Puccetti, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dendritic Cells - enzymology Dendritic Cells - immunology Female Humans Immune Tolerance - immunology Indoleamine-Pyrrole 2,3,-Dioxygenase Kynurenine - pharmacology Pregnancy Signal Transduction - immunology T-Lymphocytes - drug effects T-Lymphocytes - enzymology T-Lymphocytes - immunology Tryptophan - metabolism Tryptophan Oxygenase - physiology
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