Tolerance, DCs and tryptophan: much ado about IDO
Indoleamine 2,3-dioxygenase (IDO) degrades the indole moiety of tryptophan, serotonin and melatonin, and initiates the production of neuroactive and immunoregulatory metabolites, collectively known as kynurenines. By locally depleting tryptophan and increasing proapoptotic kynurenines, IDO expressed...
Gespeichert in:
| Veröffentlicht in: | Trends in immunology 2003-05, Vol.24 (5), p.242-248 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 248 |
|---|---|
| container_issue | 5 |
| container_start_page | 242 |
| container_title | Trends in immunology |
| container_volume | 24 |
| creator | Grohmann, Ursula Fallarino, Francesca Puccetti, Paolo |
| description | Indoleamine 2,3-dioxygenase (IDO) degrades the indole moiety of tryptophan, serotonin and melatonin, and initiates the production of neuroactive and immunoregulatory metabolites, collectively known as kynurenines. By locally depleting tryptophan and increasing proapoptotic kynurenines, IDO expressed by dendritic cells (DCs) greatly affects T-cell proliferation and survival. IDO induction in DCs could be a common mechanism of deletional tolerance driven by regulatory T cells. Because such tolerogenic responses can be expected to operate in a variety of physiopathological conditions, tryptophan metabolism and kynurenine production might represent a crucial interface between the immune and nervous systems. This Opinion is the first in a series on the
regulation of the immune system by metabolic pathways. |
| doi_str_mv | 10.1016/S1471-4906(03)00072-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73256123</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1471490603000723</els_id><sourcerecordid>73256123</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-59d8fe67521fec6ad0c1a9c0e0f5a745ba50b9323678513efff28eaf345636843</originalsourceid><addsrcrecordid>eNqFkE1Lw0AQhhdRbK3-BCUnUTA6k83upl5EWj8KhR6s52WzmaWRtqm7idB_bz-CHnuaYXjeeeFh7BLhHgHlwwemCuO0D_IG-C0AqCTmR6zbnjM8_ttBdthZCF8AKJRSp6yDieJZiqrLcFrNyZulpbtoOAiRWRZR7derulrNzPIxWjR2FpmiikxeNXU0Gk7O2Ykz80AX7eyxz9eX6eA9Hk_eRoPncWwFQh2LfpE5kkok6MhKU4BF07dA4IRRqciNgLzPEy5VJpCTcy7JyDieCslllvIeu97_Xfnqu6FQ60UZLM3nZklVE7TiiZCY8IMgZkpJTGEDij1ofRWCJ6dXvlwYv9YIeitV76TqrTENXO-k6m3BVVvQ5Asq_lOtxQ3wtAdo4-OnJK-DLWnjtCg92VoXVXmg4heKMYPF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18776140</pqid></control><display><type>article</type><title>Tolerance, DCs and tryptophan: much ado about IDO</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Grohmann, Ursula ; Fallarino, Francesca ; Puccetti, Paolo</creator><creatorcontrib>Grohmann, Ursula ; Fallarino, Francesca ; Puccetti, Paolo</creatorcontrib><description>Indoleamine 2,3-dioxygenase (IDO) degrades the indole moiety of tryptophan, serotonin and melatonin, and initiates the production of neuroactive and immunoregulatory metabolites, collectively known as kynurenines. By locally depleting tryptophan and increasing proapoptotic kynurenines, IDO expressed by dendritic cells (DCs) greatly affects T-cell proliferation and survival. IDO induction in DCs could be a common mechanism of deletional tolerance driven by regulatory T cells. Because such tolerogenic responses can be expected to operate in a variety of physiopathological conditions, tryptophan metabolism and kynurenine production might represent a crucial interface between the immune and nervous systems. This Opinion is the first in a series on the
regulation of the immune system by metabolic pathways.</description><identifier>ISSN: 1471-4906</identifier><identifier>EISSN: 1471-4981</identifier><identifier>DOI: 10.1016/S1471-4906(03)00072-3</identifier><identifier>PMID: 12738417</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Dendritic Cells - enzymology ; Dendritic Cells - immunology ; Female ; Humans ; Immune Tolerance - immunology ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Kynurenine - pharmacology ; Pregnancy ; Signal Transduction - immunology ; T-Lymphocytes - drug effects ; T-Lymphocytes - enzymology ; T-Lymphocytes - immunology ; Tryptophan - metabolism ; Tryptophan Oxygenase - physiology</subject><ispartof>Trends in immunology, 2003-05, Vol.24 (5), p.242-248</ispartof><rights>2003 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-59d8fe67521fec6ad0c1a9c0e0f5a745ba50b9323678513efff28eaf345636843</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1471490603000723$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12738417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grohmann, Ursula</creatorcontrib><creatorcontrib>Fallarino, Francesca</creatorcontrib><creatorcontrib>Puccetti, Paolo</creatorcontrib><title>Tolerance, DCs and tryptophan: much ado about IDO</title><title>Trends in immunology</title><addtitle>Trends Immunol</addtitle><description>Indoleamine 2,3-dioxygenase (IDO) degrades the indole moiety of tryptophan, serotonin and melatonin, and initiates the production of neuroactive and immunoregulatory metabolites, collectively known as kynurenines. By locally depleting tryptophan and increasing proapoptotic kynurenines, IDO expressed by dendritic cells (DCs) greatly affects T-cell proliferation and survival. IDO induction in DCs could be a common mechanism of deletional tolerance driven by regulatory T cells. Because such tolerogenic responses can be expected to operate in a variety of physiopathological conditions, tryptophan metabolism and kynurenine production might represent a crucial interface between the immune and nervous systems. This Opinion is the first in a series on the
regulation of the immune system by metabolic pathways.</description><subject>Animals</subject><subject>Dendritic Cells - enzymology</subject><subject>Dendritic Cells - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immune Tolerance - immunology</subject><subject>Indoleamine-Pyrrole 2,3,-Dioxygenase</subject><subject>Kynurenine - pharmacology</subject><subject>Pregnancy</subject><subject>Signal Transduction - immunology</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - enzymology</subject><subject>T-Lymphocytes - immunology</subject><subject>Tryptophan - metabolism</subject><subject>Tryptophan Oxygenase - physiology</subject><issn>1471-4906</issn><issn>1471-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRbK3-BCUnUTA6k83upl5EWj8KhR6s52WzmaWRtqm7idB_bz-CHnuaYXjeeeFh7BLhHgHlwwemCuO0D_IG-C0AqCTmR6zbnjM8_ttBdthZCF8AKJRSp6yDieJZiqrLcFrNyZulpbtoOAiRWRZR7derulrNzPIxWjR2FpmiikxeNXU0Gk7O2Ykz80AX7eyxz9eX6eA9Hk_eRoPncWwFQh2LfpE5kkok6MhKU4BF07dA4IRRqciNgLzPEy5VJpCTcy7JyDieCslllvIeu97_Xfnqu6FQ60UZLM3nZklVE7TiiZCY8IMgZkpJTGEDij1ofRWCJ6dXvlwYv9YIeitV76TqrTENXO-k6m3BVVvQ5Asq_lOtxQ3wtAdo4-OnJK-DLWnjtCg92VoXVXmg4heKMYPF</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Grohmann, Ursula</creator><creator>Fallarino, Francesca</creator><creator>Puccetti, Paolo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Tolerance, DCs and tryptophan: much ado about IDO</title><author>Grohmann, Ursula ; Fallarino, Francesca ; Puccetti, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-59d8fe67521fec6ad0c1a9c0e0f5a745ba50b9323678513efff28eaf345636843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Dendritic Cells - enzymology</topic><topic>Dendritic Cells - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immune Tolerance - immunology</topic><topic>Indoleamine-Pyrrole 2,3,-Dioxygenase</topic><topic>Kynurenine - pharmacology</topic><topic>Pregnancy</topic><topic>Signal Transduction - immunology</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - enzymology</topic><topic>T-Lymphocytes - immunology</topic><topic>Tryptophan - metabolism</topic><topic>Tryptophan Oxygenase - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grohmann, Ursula</creatorcontrib><creatorcontrib>Fallarino, Francesca</creatorcontrib><creatorcontrib>Puccetti, Paolo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grohmann, Ursula</au><au>Fallarino, Francesca</au><au>Puccetti, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tolerance, DCs and tryptophan: much ado about IDO</atitle><jtitle>Trends in immunology</jtitle><addtitle>Trends Immunol</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>24</volume><issue>5</issue><spage>242</spage><epage>248</epage><pages>242-248</pages><issn>1471-4906</issn><eissn>1471-4981</eissn><abstract>Indoleamine 2,3-dioxygenase (IDO) degrades the indole moiety of tryptophan, serotonin and melatonin, and initiates the production of neuroactive and immunoregulatory metabolites, collectively known as kynurenines. By locally depleting tryptophan and increasing proapoptotic kynurenines, IDO expressed by dendritic cells (DCs) greatly affects T-cell proliferation and survival. IDO induction in DCs could be a common mechanism of deletional tolerance driven by regulatory T cells. Because such tolerogenic responses can be expected to operate in a variety of physiopathological conditions, tryptophan metabolism and kynurenine production might represent a crucial interface between the immune and nervous systems. This Opinion is the first in a series on the
regulation of the immune system by metabolic pathways.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>12738417</pmid><doi>10.1016/S1471-4906(03)00072-3</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1471-4906 |
| ispartof | Trends in immunology, 2003-05, Vol.24 (5), p.242-248 |
| issn | 1471-4906 1471-4981 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73256123 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Dendritic Cells - enzymology Dendritic Cells - immunology Female Humans Immune Tolerance - immunology Indoleamine-Pyrrole 2,3,-Dioxygenase Kynurenine - pharmacology Pregnancy Signal Transduction - immunology T-Lymphocytes - drug effects T-Lymphocytes - enzymology T-Lymphocytes - immunology Tryptophan - metabolism Tryptophan Oxygenase - physiology |
| title | Tolerance, DCs and tryptophan: much ado about IDO |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T18%3A23%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tolerance,%20DCs%20and%20tryptophan:%20much%20ado%20about%20IDO&rft.jtitle=Trends%20in%20immunology&rft.au=Grohmann,%20Ursula&rft.date=2003-05-01&rft.volume=24&rft.issue=5&rft.spage=242&rft.epage=248&rft.pages=242-248&rft.issn=1471-4906&rft.eissn=1471-4981&rft_id=info:doi/10.1016/S1471-4906(03)00072-3&rft_dat=%3Cproquest_cross%3E73256123%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18776140&rft_id=info:pmid/12738417&rft_els_id=S1471490603000723&rfr_iscdi=true |