Bark, Weeds, and Iron Chelators — Drugs for Malaria
Over the millennia that humanity has struggled against malaria, some successes in controlling this scourge have been achieved from time to time through both empirical efforts and rational design. The development in the early 1970s of methods to cultivate Plasmodium falciparum in vitro 1 was a major...
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| Veröffentlicht in: | The New England journal of medicine 1992-11, Vol.327 (21), p.1519-1521 |
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| container_issue | 21 |
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| container_title | The New England journal of medicine |
| container_volume | 327 |
| creator | Wyler, David J |
| description | Over the millennia that humanity has struggled against malaria, some successes in controlling this scourge have been achieved from time to time through both empirical efforts and rational design. The development in the early 1970s of methods to cultivate
Plasmodium falciparum
in vitro
1
was a major breakthrough because it facilitated studies of parasite metabolism that could lead to novel strategies for designing treatments. In this issue of the
Journal
, Gordeuk and colleagues report the results of a clinical trial of iron-chelation therapy in children with cerebral malaria.
2
This trial is an example of the practical application of knowledge obtained . . . |
| doi_str_mv | 10.1056/NEJM199211193272110 |
| format | Article |
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Plasmodium falciparum
in vitro
1
was a major breakthrough because it facilitated studies of parasite metabolism that could lead to novel strategies for designing treatments. In this issue of the
Journal
, Gordeuk and colleagues report the results of a clinical trial of iron-chelation therapy in children with cerebral malaria.
2
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Plasmodium falciparum
in vitro
1
was a major breakthrough because it facilitated studies of parasite metabolism that could lead to novel strategies for designing treatments. In this issue of the
Journal
, Gordeuk and colleagues report the results of a clinical trial of iron-chelation therapy in children with cerebral malaria.
2
This trial is an example of the practical application of knowledge obtained . . .</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimalarials - therapeutic use</subject><subject>Antiparasitic agents</subject><subject>Artemisia annua</subject><subject>Bark</subject><subject>Biological and medical sciences</subject><subject>Chelating agents</subject><subject>Chelation therapy</subject><subject>Child</subject><subject>Deferoxamine - therapeutic use</subject><subject>Drugs</subject><subject>Erythrocytes</subject><subject>Humans</subject><subject>Infections</subject><subject>Iron</subject><subject>Malaria</subject><subject>Malaria, Cerebral - drug therapy</subject><subject>Malaria, Falciparum - drug therapy</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Mortality</subject><subject>Parasites</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasmodium falciparum</subject><subject>Proteins</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kMlKA0EQhhtRNEafQIRBxYsZ7eq9jxp3XC4Bj0Onp0cTZ4ndmYM3H8In9EnskKAgal0K6v9q-xHaAnwImIuju7PrW9CaAICmRMaMl1AHOKUpY1gsow7GRKVMarqG1kMY4xjA9CpahagrxTqInxj_3EsenMtDLzF1nlz5pk76T64008aH5OPtPTn17WNIisYnt6Y0fmQ20EphyuA2F7mLBudng_5lenN_cdU_vkktI3ia6pwzw4h0NpeUgh1qFSswxFI4JokzQgsnC0qJwIqDzRUQzBUnVgsqgHbR_nzsxDcvrQvTrBoF68rS1K5pQyYp4Xz2bxft_ADHTevreFpGCNUcQMkI7f4FgVaU8eiJiBSdU9Y3IXhXZBM_qox_zQBnM9uzX2yPXduL2e2wcvl3z9znqO8tdBOsKQtvajsKXxhjigimI3Ywx6oqZLUbV_8u_QQrA5Eg</recordid><startdate>19921119</startdate><enddate>19921119</enddate><creator>Wyler, David J</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19921119</creationdate><title>Bark, Weeds, and Iron Chelators — Drugs for Malaria</title><author>Wyler, David J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-9d54a427ecd7331cb98d541b076e472ea696e7f33260851cd81205852c963613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antimalarials - therapeutic use</topic><topic>Antiparasitic agents</topic><topic>Artemisia annua</topic><topic>Bark</topic><topic>Biological and medical sciences</topic><topic>Chelating agents</topic><topic>Chelation therapy</topic><topic>Child</topic><topic>Deferoxamine - therapeutic use</topic><topic>Drugs</topic><topic>Erythrocytes</topic><topic>Humans</topic><topic>Infections</topic><topic>Iron</topic><topic>Malaria</topic><topic>Malaria, Cerebral - drug therapy</topic><topic>Malaria, Falciparum - drug therapy</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Mortality</topic><topic>Parasites</topic><topic>Pharmacology. 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The development in the early 1970s of methods to cultivate
Plasmodium falciparum
in vitro
1
was a major breakthrough because it facilitated studies of parasite metabolism that could lead to novel strategies for designing treatments. In this issue of the
Journal
, Gordeuk and colleagues report the results of a clinical trial of iron-chelation therapy in children with cerebral malaria.
2
This trial is an example of the practical application of knowledge obtained . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>1406884</pmid><doi>10.1056/NEJM199211193272110</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1992-11, Vol.327 (21), p.1519-1521 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73255153 |
| source | MEDLINE; New England Journal of Medicine Current; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - therapeutic use Antiparasitic agents Artemisia annua Bark Biological and medical sciences Chelating agents Chelation therapy Child Deferoxamine - therapeutic use Drugs Erythrocytes Humans Infections Iron Malaria Malaria, Cerebral - drug therapy Malaria, Falciparum - drug therapy Medical sciences Metabolism Metabolites Mortality Parasites Pharmacology. Drug treatments Plasmodium falciparum Proteins |
| title | Bark, Weeds, and Iron Chelators — Drugs for Malaria |
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