The Amygdala, Fear, and Memory
: Lesions of the frontotemporal region of the amygdala, which includes lateral and basal nuclei, cause a loss of conditional fear responses, such as freezing, even when the lesions are made over a year and a half from the original training. These amygdala‐damaged animals are not hyperactive and show...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2003-04, Vol.985 (1), p.125-134 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | FANSELOW, MICHAEL S. GALE, GREG D. |
| description | : Lesions of the frontotemporal region of the amygdala, which includes lateral and basal nuclei, cause a loss of conditional fear responses, such as freezing, even when the lesions are made over a year and a half from the original training. These amygdala‐damaged animals are not hyperactive and show normal reactivity to strong stimuli such as bright lights. After receiving tone‐mild shock pairings rats normally display an appropriately weak response when exposed to the tone. Rats' fear of the tone can be inflated by giving them exposure to strong shocks in the absence of the tone between training and testing. This inflation of fear memory is abolished if the frontotemporal amygdala is inactivated by muscimol only during the inflation treatment with strong shocks. Based on such findings we suggest that the frontotemporal amygdala permanently encodes a memory for the hedonic value of the aversive stimulus used to condition fear. |
| doi_str_mv | 10.1111/j.1749-6632.2003.tb07077.x |
| format | Article |
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Based on such findings we suggest that the frontotemporal amygdala permanently encodes a memory for the hedonic value of the aversive stimulus used to condition fear.</description><subject>affect</subject><subject>Amnesia, Retrograde - physiopathology</subject><subject>amygdala</subject><subject>Amygdala - physiology</subject><subject>Animals</subject><subject>basolateral amygdala</subject><subject>Conditioning, Operant</subject><subject>fear</subject><subject>Fear - physiology</subject><subject>freezing</subject><subject>frontotemporal amygdala</subject><subject>hedonic value</subject><subject>hippocampus</subject><subject>memory</subject><subject>Memory - physiology</subject><subject>Models, Animal</subject><subject>pavlovian conditioning</subject><subject>retrograde amnesia</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1PwjAUhhujEUT_Alm88IrNfq6dN4YQARNEoxjiVXO2FR1uDFeI7N-7ZYte25um57zv0-RB6JJgj1Tneu0RyQPX9xn1KMbM24VYYim9wxHq_q6OURdXQ1cFlHXQmbVrjAlVXJ6iDqGSciJ4F_UXH8YZZuV7DCkMnLGBYuDAJnYeTJYX5Tk6WUFqzUV799Dr-G4xmrqzx8n9aDhzIy6FcJkEUCwyEIWUABe-iLjASiigccB9ZSRX1VuyAGIBSkifSliFgaEgTERD1kNXDXdb5F97Y3c6S2xk0hQ2Jt9bLRkVgnC_Ct40wajIrS3MSm-LJIOi1ATr2o5e61qBrhXo2o5u7ehDVe63v-zDzMR_1VZHFbhtAt9Jasp_oPX8bfhCqKgIbkNI7M4cfglQfGpfMin0cj7Rz098yjBZasZ-ANbhgMw</recordid><startdate>200304</startdate><enddate>200304</enddate><creator>FANSELOW, MICHAEL S.</creator><creator>GALE, GREG D.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200304</creationdate><title>The Amygdala, Fear, and Memory</title><author>FANSELOW, MICHAEL S. ; GALE, GREG D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4755-37aa83ceacb21a4565c450858a2d9468e748508739ad5a857627afb9e2a5ec2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>affect</topic><topic>Amnesia, Retrograde - physiopathology</topic><topic>amygdala</topic><topic>Amygdala - physiology</topic><topic>Animals</topic><topic>basolateral amygdala</topic><topic>Conditioning, Operant</topic><topic>fear</topic><topic>Fear - physiology</topic><topic>freezing</topic><topic>frontotemporal amygdala</topic><topic>hedonic value</topic><topic>hippocampus</topic><topic>memory</topic><topic>Memory - physiology</topic><topic>Models, Animal</topic><topic>pavlovian conditioning</topic><topic>retrograde amnesia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FANSELOW, MICHAEL S.</creatorcontrib><creatorcontrib>GALE, GREG D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FANSELOW, MICHAEL S.</au><au>GALE, GREG D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Amygdala, Fear, and Memory</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2003-04</date><risdate>2003</risdate><volume>985</volume><issue>1</issue><spage>125</spage><epage>134</epage><pages>125-134</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: Lesions of the frontotemporal region of the amygdala, which includes lateral and basal nuclei, cause a loss of conditional fear responses, such as freezing, even when the lesions are made over a year and a half from the original training. 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| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 2003-04, Vol.985 (1), p.125-134 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | affect Amnesia, Retrograde - physiopathology amygdala Amygdala - physiology Animals basolateral amygdala Conditioning, Operant fear Fear - physiology freezing frontotemporal amygdala hedonic value hippocampus memory Memory - physiology Models, Animal pavlovian conditioning retrograde amnesia |
| title | The Amygdala, Fear, and Memory |
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