Design, Synthesis and Biological Evaluation of Oxazolidinone–Quinolone Hybrids

Oxazolidinone–quinolone hybrids that combine the pharmacophores of a quinolone and an oxazolidinone were synthesised and shown to be active against a variety of resistant and susceptible Gram-positive and fastidious Gram-negative organisms. The best compounds in this series overcome all types of res...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2003-05, Vol.11 (10), p.2313-2319
Hauptverfasser:	Hubschwerlen, Christian, Specklin, Jean-Luc, Sigwalt, Christine, Schroeder, Susanne, Locher, Hans H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences DNA Gyrase - metabolism DNA Topoisomerase IV - metabolism Drug Design Drug Evaluation, Preclinical Drug Resistance, Multiple Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Medical sciences Microbial Sensitivity Tests Molecular Structure Oxazolidinones - chemical synthesis Oxazolidinones - chemistry Oxazolidinones - pharmacology Pharmacology. Drug treatments Protein Biosynthesis Quinolones - chemical synthesis Quinolones - chemistry Quinolones - pharmacology Structure-Activity Relationship Transcription, Genetic
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