Antipruritic Effects of Sophora flavescens on Acute and Chronic Itch-Related Responses in Mice
To find new antipruritic herbal medicines for pruritus, we screened the methanol extracts of seven herbal medicines which have been used to treat dermatologic diseases, testing them on mouse models of acute and chronic itch. When administrated perorally (p.o.) at a dose of 200 mg/kg, methanol extrac...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2003, Vol.26(5), pp.722-724 |
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| creator | Yamaguchi-Miyamoto, Tomomi Kawasuji, Toru Kuraishi, Yasushi Suzuki, Hideyo |
| description | To find new antipruritic herbal medicines for pruritus, we screened the methanol extracts of seven herbal medicines which have been used to treat dermatologic diseases, testing them on mouse models of acute and chronic itch. When administrated perorally (p.o.) at a dose of 200 mg/kg, methanol extracts of Sophora flavescens and Cnidium monnieri, but not the others, significantly inhibited a serotonin (5-HT)-induced itch-related response (scratching) and the spontaneous scratching of NC mice, a mouse model of atopic dermatitis. The inhibitory effect of Sophora flavescens was stronger than that of Cnidium monnieri. The methanol extract from Sophora flavescens (50—200 mg/kg) inhibited 5-HT-induced scratching in a dose-dependent manner, without any effects on the locomotor activity. These results suggest that Sophora flavescens and its constituents widely affect acute and chronic pruritus, and are possible as new antipruritic agents. |
| doi_str_mv | 10.1248/bpb.26.722 |
| format | Article |
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When administrated perorally (p.o.) at a dose of 200 mg/kg, methanol extracts of Sophora flavescens and Cnidium monnieri, but not the others, significantly inhibited a serotonin (5-HT)-induced itch-related response (scratching) and the spontaneous scratching of NC mice, a mouse model of atopic dermatitis. The inhibitory effect of Sophora flavescens was stronger than that of Cnidium monnieri. The methanol extract from Sophora flavescens (50—200 mg/kg) inhibited 5-HT-induced scratching in a dose-dependent manner, without any effects on the locomotor activity. These results suggest that Sophora flavescens and its constituents widely affect acute and chronic pruritus, and are possible as new antipruritic agents.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.26.722</identifier><identifier>PMID: 12736520</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Acute Disease ; Administration, Oral ; Animals ; Antipruritics - administration & dosage ; Antipruritics - therapeutic use ; atopic dermatitis ; Behavior, Animal ; Biological and medical sciences ; Chronic Disease ; Disease Models, Animal ; herbal medicine ; itch ; Male ; Medical sciences ; Mice ; Mice, Inbred ICR ; Motor Activity - drug effects ; NC mice ; Phytotherapy ; Plant Extracts - pharmacology ; Pruritus - drug therapy ; serotonin ; Sophora - chemistry</subject><ispartof>Biological and Pharmaceutical Bulletin, 2003, Vol.26(5), pp.722-724</ispartof><rights>2003 The Pharmaceutical Society of Japan</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c649t-8f9a30138bea84871c2f350cd32688ebd84ae06ac7823272c11bb375497a5e0a3</citedby><cites>FETCH-LOGICAL-c649t-8f9a30138bea84871c2f350cd32688ebd84ae06ac7823272c11bb375497a5e0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14863294$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12736520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamaguchi-Miyamoto, Tomomi</creatorcontrib><creatorcontrib>Kawasuji, Toru</creatorcontrib><creatorcontrib>Kuraishi, Yasushi</creatorcontrib><creatorcontrib>Suzuki, Hideyo</creatorcontrib><title>Antipruritic Effects of Sophora flavescens on Acute and Chronic Itch-Related Responses in Mice</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>To find new antipruritic herbal medicines for pruritus, we screened the methanol extracts of seven herbal medicines which have been used to treat dermatologic diseases, testing them on mouse models of acute and chronic itch. When administrated perorally (p.o.) at a dose of 200 mg/kg, methanol extracts of Sophora flavescens and Cnidium monnieri, but not the others, significantly inhibited a serotonin (5-HT)-induced itch-related response (scratching) and the spontaneous scratching of NC mice, a mouse model of atopic dermatitis. The inhibitory effect of Sophora flavescens was stronger than that of Cnidium monnieri. The methanol extract from Sophora flavescens (50—200 mg/kg) inhibited 5-HT-induced scratching in a dose-dependent manner, without any effects on the locomotor activity. These results suggest that Sophora flavescens and its constituents widely affect acute and chronic pruritus, and are possible as new antipruritic agents.</description><subject>Acute Disease</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Antipruritics - administration & dosage</subject><subject>Antipruritics - therapeutic use</subject><subject>atopic dermatitis</subject><subject>Behavior, Animal</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Disease Models, Animal</subject><subject>herbal medicine</subject><subject>itch</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Motor Activity - drug effects</subject><subject>NC mice</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Pruritus - drug therapy</subject><subject>serotonin</subject><subject>Sophora - chemistry</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0V1rFDEUBuAgFrtWb_wBEhC9EGab72SuZFmqFloKVW8NZzJn3FlmM2MyI_jvjezagjcJJE_OObwh5BVnay6Uu2ymZi3M2grxhKy4VLbSguunZMVq7irDtTsnz3PeM8YsE_IZOefCSqMFW5Hvmzj3U1pSP_eBXnUdhjnTsaNfxmk3JqDdAL8wB4zlNNJNWGakEFu63aUxlifXc9hV9zjAjC29xzyNMWOmfaS3fcAX5KyDIePL035Bvn28-rr9XN3cfbrebm6qYFQ9V66rQTIuXYPglLM8iE5qFlopjHPYtE4BMgPBOiGFFYHzppFWq9qCRgbygrw71p3S-HPBPPtDX4YeBog4LtlbKbRi0hT45j-4H5cUy2yeK1VLJrmzRb0_qpDGnBN2fkr9AdJvz5n_m7kvmXthfMm84NenkktzwPaRnkIu4O0JQA4wdAli6POjU85IUaviPhzdPs_wAx8ApPI3A_7rqY9Laf1wE3aQPEb5B98fnu8</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Yamaguchi-Miyamoto, Tomomi</creator><creator>Kawasuji, Toru</creator><creator>Kuraishi, Yasushi</creator><creator>Suzuki, Hideyo</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Antipruritic Effects of Sophora flavescens on Acute and Chronic Itch-Related Responses in Mice</title><author>Yamaguchi-Miyamoto, Tomomi ; Kawasuji, Toru ; Kuraishi, Yasushi ; Suzuki, Hideyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c649t-8f9a30138bea84871c2f350cd32688ebd84ae06ac7823272c11bb375497a5e0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acute Disease</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>Antipruritics - administration & dosage</topic><topic>Antipruritics - therapeutic use</topic><topic>atopic dermatitis</topic><topic>Behavior, Animal</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Disease Models, Animal</topic><topic>herbal medicine</topic><topic>itch</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Motor Activity - drug effects</topic><topic>NC mice</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Pruritus - drug therapy</topic><topic>serotonin</topic><topic>Sophora - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamaguchi-Miyamoto, Tomomi</creatorcontrib><creatorcontrib>Kawasuji, Toru</creatorcontrib><creatorcontrib>Kuraishi, Yasushi</creatorcontrib><creatorcontrib>Suzuki, Hideyo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamaguchi-Miyamoto, Tomomi</au><au>Kawasuji, Toru</au><au>Kuraishi, Yasushi</au><au>Suzuki, Hideyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antipruritic Effects of Sophora flavescens on Acute and Chronic Itch-Related Responses in Mice</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>26</volume><issue>5</issue><spage>722</spage><epage>724</epage><pages>722-724</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>To find new antipruritic herbal medicines for pruritus, we screened the methanol extracts of seven herbal medicines which have been used to treat dermatologic diseases, testing them on mouse models of acute and chronic itch. When administrated perorally (p.o.) at a dose of 200 mg/kg, methanol extracts of Sophora flavescens and Cnidium monnieri, but not the others, significantly inhibited a serotonin (5-HT)-induced itch-related response (scratching) and the spontaneous scratching of NC mice, a mouse model of atopic dermatitis. The inhibitory effect of Sophora flavescens was stronger than that of Cnidium monnieri. The methanol extract from Sophora flavescens (50—200 mg/kg) inhibited 5-HT-induced scratching in a dose-dependent manner, without any effects on the locomotor activity. These results suggest that Sophora flavescens and its constituents widely affect acute and chronic pruritus, and are possible as new antipruritic agents.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>12736520</pmid><doi>10.1248/bpb.26.722</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Administration, Oral Animals Antipruritics - administration & dosage Antipruritics - therapeutic use atopic dermatitis Behavior, Animal Biological and medical sciences Chronic Disease Disease Models, Animal herbal medicine itch Male Medical sciences Mice Mice, Inbred ICR Motor Activity - drug effects NC mice Phytotherapy Plant Extracts - pharmacology Pruritus - drug therapy serotonin Sophora - chemistry |
| title | Antipruritic Effects of Sophora flavescens on Acute and Chronic Itch-Related Responses in Mice |
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