C-Receptor Ligand Blocks Pulmonary Clearance of Atrial Natriuretic Peptide in Isolated Rat Lungs
Abstract Pulmonary clearance of atrial natriuretic peptide (ANP) was measured by indicator dilution technique in isolated perfused rat lungs with and without ANP clearance receptor (C-receptor) blockade. Approximately 50% of a bolus injection of 125I-ANP was removed during a single pass through the...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1992-11, Vol.201 (2), p.154-158 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
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| creator | Klinger, James R. Moalli, Richard Warburton, Rod R. Wrenn, David S. Hill, Nicholas S. |
| description | Abstract
Pulmonary clearance of atrial natriuretic peptide (ANP) was measured by indicator dilution technique in isolated perfused rat lungs with and without ANP clearance receptor (C-receptor) blockade. Approximately 50% of a bolus injection of 125I-ANP was removed during a single pass through the lungs compared with the intravascular marker 14C-dextran. Pulmonary clearance of 125I-ANP was suppressed in a dose-dependent fashion by unlabeled ANP, C-receptor blockade suppressed pulmonary clearance of 125I-ANP to the same degree as unlabeled ANP. High-performance liquid chromatography analysis of the pulmonary venous effluent from lungs treated with C-receptor ligand demonstrated intact 125I-ANP. We conclude that virtually all of the pulmonary vascular uptake of 125I-ANP during a single pass through isolated lungs is secondary to removal by ANP C-receptors. |
| doi_str_mv | 10.3181/00379727-201-43494A |
| format | Article |
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Pulmonary clearance of atrial natriuretic peptide (ANP) was measured by indicator dilution technique in isolated perfused rat lungs with and without ANP clearance receptor (C-receptor) blockade. Approximately 50% of a bolus injection of 125I-ANP was removed during a single pass through the lungs compared with the intravascular marker 14C-dextran. Pulmonary clearance of 125I-ANP was suppressed in a dose-dependent fashion by unlabeled ANP, C-receptor blockade suppressed pulmonary clearance of 125I-ANP to the same degree as unlabeled ANP. High-performance liquid chromatography analysis of the pulmonary venous effluent from lungs treated with C-receptor ligand demonstrated intact 125I-ANP. We conclude that virtually all of the pulmonary vascular uptake of 125I-ANP during a single pass through isolated lungs is secondary to removal by ANP C-receptors.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>EISSN: 1525-1373</identifier><identifier>DOI: 10.3181/00379727-201-43494A</identifier><identifier>PMID: 1409730</identifier><identifier>CODEN: PSEBAA</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Atrial Natriuretic Factor - metabolism ; Atrial Natriuretic Factor - pharmacology ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Fundamental and applied biological sciences. Psychology ; Iodine Radioisotopes ; Lung - drug effects ; Lung - metabolism ; Male ; Peptide Fragments - metabolism ; Peptide Fragments - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Atrial Natriuretic Factor - metabolism ; Vertebrates: endocrinology</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1992-11, Vol.201 (2), p.154-158</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-8247a20cab749a6624000625c47fd163fabdc4b768722e362d0dad8f8044384a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4387460$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1409730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klinger, James R.</creatorcontrib><creatorcontrib>Moalli, Richard</creatorcontrib><creatorcontrib>Warburton, Rod R.</creatorcontrib><creatorcontrib>Wrenn, David S.</creatorcontrib><creatorcontrib>Hill, Nicholas S.</creatorcontrib><title>C-Receptor Ligand Blocks Pulmonary Clearance of Atrial Natriuretic Peptide in Isolated Rat Lungs</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
Pulmonary clearance of atrial natriuretic peptide (ANP) was measured by indicator dilution technique in isolated perfused rat lungs with and without ANP clearance receptor (C-receptor) blockade. Approximately 50% of a bolus injection of 125I-ANP was removed during a single pass through the lungs compared with the intravascular marker 14C-dextran. Pulmonary clearance of 125I-ANP was suppressed in a dose-dependent fashion by unlabeled ANP, C-receptor blockade suppressed pulmonary clearance of 125I-ANP to the same degree as unlabeled ANP. High-performance liquid chromatography analysis of the pulmonary venous effluent from lungs treated with C-receptor ligand demonstrated intact 125I-ANP. We conclude that virtually all of the pulmonary vascular uptake of 125I-ANP during a single pass through isolated lungs is secondary to removal by ANP C-receptors.</description><subject>Animals</subject><subject>Atrial Natriuretic Factor - metabolism</subject><subject>Atrial Natriuretic Factor - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Iodine Radioisotopes</subject><subject>Lung - drug effects</subject><subject>Lung - metabolism</subject><subject>Male</subject><subject>Peptide Fragments - metabolism</subject><subject>Peptide Fragments - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Atrial Natriuretic Factor - metabolism</subject><subject>Vertebrates: endocrinology</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><issn>1525-1373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1UVJaFX1BV8qHiFhh_xE6Oy6pApRVUFZzNrO2s0nrjxU4O_HscZSk3TnOY552Ph5ArBu8Fa9gHAKFbzXXFgVVSyFZuXpAVq0VdCdW2F2Q1E9WMvCKvc34EYLXm6pJcMgmtFrAiP7fVg7f-NMZEd_0BB0c_hmifMr2fwjEOmH7TbfCYcLCexo5uxtRjoF-x1Cn5sbf0vsR752k_0LscA47e0Qcc6W4aDvkNedlhyP7tua7Jj0-337dfqt23z3fbza6yQsNYNVxq5GBxr2WLSnEJAIrXVurOMSU63Dsr91o1mnMvFHfg0DVdA1KKRqJYk3fL3FOKvyafR3Pss_Uh4ODjlI0WvOatEAUUC2hTzDn5zpxSfyx_GgZm9mr-ejXFq1m8ltT1efy0P3r3L7OILP2bcx-zxdDNvvr8jJUbtVQzBguW8eDNY5zSUKT8d_Mf0GSMnw</recordid><startdate>19921101</startdate><enddate>19921101</enddate><creator>Klinger, James R.</creator><creator>Moalli, Richard</creator><creator>Warburton, Rod R.</creator><creator>Wrenn, David S.</creator><creator>Hill, Nicholas S.</creator><general>SAGE Publications</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19921101</creationdate><title>C-Receptor Ligand Blocks Pulmonary Clearance of Atrial Natriuretic Peptide in Isolated Rat Lungs</title><author>Klinger, James R. ; Moalli, Richard ; Warburton, Rod R. ; Wrenn, David S. ; Hill, Nicholas S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-8247a20cab749a6624000625c47fd163fabdc4b768722e362d0dad8f8044384a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Atrial Natriuretic Factor - metabolism</topic><topic>Atrial Natriuretic Factor - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Iodine Radioisotopes</topic><topic>Lung - drug effects</topic><topic>Lung - metabolism</topic><topic>Male</topic><topic>Peptide Fragments - metabolism</topic><topic>Peptide Fragments - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Atrial Natriuretic Factor - metabolism</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klinger, James R.</creatorcontrib><creatorcontrib>Moalli, Richard</creatorcontrib><creatorcontrib>Warburton, Rod R.</creatorcontrib><creatorcontrib>Wrenn, David S.</creatorcontrib><creatorcontrib>Hill, Nicholas S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klinger, James R.</au><au>Moalli, Richard</au><au>Warburton, Rod R.</au><au>Wrenn, David S.</au><au>Hill, Nicholas S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C-Receptor Ligand Blocks Pulmonary Clearance of Atrial Natriuretic Peptide in Isolated Rat Lungs</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1992-11-01</date><risdate>1992</risdate><volume>201</volume><issue>2</issue><spage>154</spage><epage>158</epage><pages>154-158</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><eissn>1525-1373</eissn><coden>PSEBAA</coden><abstract>Abstract
Pulmonary clearance of atrial natriuretic peptide (ANP) was measured by indicator dilution technique in isolated perfused rat lungs with and without ANP clearance receptor (C-receptor) blockade. Approximately 50% of a bolus injection of 125I-ANP was removed during a single pass through the lungs compared with the intravascular marker 14C-dextran. Pulmonary clearance of 125I-ANP was suppressed in a dose-dependent fashion by unlabeled ANP, C-receptor blockade suppressed pulmonary clearance of 125I-ANP to the same degree as unlabeled ANP. High-performance liquid chromatography analysis of the pulmonary venous effluent from lungs treated with C-receptor ligand demonstrated intact 125I-ANP. We conclude that virtually all of the pulmonary vascular uptake of 125I-ANP during a single pass through isolated lungs is secondary to removal by ANP C-receptors.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>1409730</pmid><doi>10.3181/00379727-201-43494A</doi><tpages>5</tpages></addata></record> |
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| ispartof | Experimental biology and medicine (Maywood, N.J.), 1992-11, Vol.201 (2), p.154-158 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Atrial Natriuretic Factor - metabolism Atrial Natriuretic Factor - pharmacology Biological and medical sciences Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Iodine Radioisotopes Lung - drug effects Lung - metabolism Male Peptide Fragments - metabolism Peptide Fragments - pharmacology Rats Rats, Sprague-Dawley Receptors, Atrial Natriuretic Factor - metabolism Vertebrates: endocrinology |
| title | C-Receptor Ligand Blocks Pulmonary Clearance of Atrial Natriuretic Peptide in Isolated Rat Lungs |
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