Reactive and reparative myocardial fibrosis in arterial hypertension in the rat

Objective: Myocardial fibrosis is an important determinant of pathological hypertrophy. In two experimental models of arterial hypertension the purpose of the study was (a) to determine total collagen volume fraction and relative contribution of scarring and perivascular/interstitial fibrosis; and (...

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Veröffentlicht in:	Cardiovascular research 1992-07, Vol.26 (7), p.671-677
Hauptverfasser:	Brilla, Christian G, Weber, Karl T
Format:	Artikel
Sprache:	eng
Schlagworte:	aldosterone Aldosterone - blood Aldosterone - pharmacology Angiotensin II - blood Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiomegaly - blood Cardiomegaly - metabolism Cardiomegaly - pathology Collagen - metabolism Disease Models, Animal Experimental diseases Fibrosis hypertension Hypertension, Renovascular - blood Hypertension, Renovascular - metabolism Hypertension, Renovascular - pathology Male Medical sciences myocardial fibrosis Myocardium - metabolism Myocardium - pathology Rats Rats, Sprague-Dawley Sodium, Dietary - administration & dosage Spironolactone - pharmacology
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