Tachykinin peptide-induced activation and desensitization of neurokinin 1 receptors

The actions of four tachykinins on inhibition and desensitization of the M-current of bullfrog sympathetic neurons have been characterized. Radioligand binding parameters of the tachykinins were determined at a neurokinin receptor in a heterologous expression system. The correlation between binding,...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2003-03, Vol.24 (3), p.469-475
Hauptverfasser:	Perrine, S.A., Bennett, V.J., Simmons, M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Bullfrog sympathetic ganglia CHO Cells Cricetinae Desensitization Down-Regulation - drug effects Electrophysiology Fundamental and applied biological sciences. Psychology Ligands M-current Neurokinin 1 receptor Potassium - metabolism Protein Binding Rana catesbeiana Receptors, Neurokinin-1 - agonists Receptors, Neurokinin-1 - metabolism Substance P Tachykinin Tachykinins - chemistry Tachykinins - pharmacology
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