In vitro activity of amphotericin B and itraconazole in combination with flucytosine, sulfadiazine and quinolones against Exophiala spinifera
The combined effects of antifungal and antibiotic drugs against Exophiala spinifera were evaluated in vitro by the chequer-board method, calculated as a fractional inhibitory concentration (FIC) index. Amphotericin B was combined with flucytosine and ciprofloxacin, whereas itraconazole was combined...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2003-05, Vol.51 (5), p.1297-1300 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Vitale, R. G. Afeltra, J. de Hoog, G. S. Rijs, A. J. Verweij, P. E. |
| description | The combined effects of antifungal and antibiotic drugs against Exophiala spinifera were evaluated in vitro by the chequer-board method, calculated as a fractional inhibitory concentration (FIC) index. Amphotericin B was combined with flucytosine and ciprofloxacin, whereas itraconazole was combined with ciprofloxacin, levofloxacin, lomefloxacin and sulfadiazine. Synergic effects were observed for the combinations of itraconazole with ciprofloxacin and levofloxacin, and amphotericin B with ciprofloxacin and flucytosine. No antagonism was observed for any combination tested. |
| doi_str_mv | 10.1093/jac/dkg218 |
| format | Article |
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G. ; Afeltra, J. ; de Hoog, G. S. ; Rijs, A. J. ; Verweij, P. E.</creator><creatorcontrib>Vitale, R. G. ; Afeltra, J. ; de Hoog, G. S. ; Rijs, A. J. ; Verweij, P. E.</creatorcontrib><description>The combined effects of antifungal and antibiotic drugs against Exophiala spinifera were evaluated in vitro by the chequer-board method, calculated as a fractional inhibitory concentration (FIC) index. Amphotericin B was combined with flucytosine and ciprofloxacin, whereas itraconazole was combined with ciprofloxacin, levofloxacin, lomefloxacin and sulfadiazine. Synergic effects were observed for the combinations of itraconazole with ciprofloxacin and levofloxacin, and amphotericin B with ciprofloxacin and flucytosine. No antagonism was observed for any combination tested.</description><identifier>ISSN: 0305-7453</identifier><identifier>ISSN: 1460-2091</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dkg218</identifier><identifier>PMID: 12697648</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Amphotericin B - pharmacology ; Anti-Infective Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - pharmacology ; Biological and medical sciences ; black yeasts ; Drug Combinations ; Exophiala ; Exophiala - drug effects ; Exophiala spinifera ; Flucytosine - pharmacology ; Itraconazole - pharmacology ; lomefloxacin ; Medical sciences ; Microbial Sensitivity Tests ; Pharmacology. 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G.</creatorcontrib><creatorcontrib>Afeltra, J.</creatorcontrib><creatorcontrib>de Hoog, G. S.</creatorcontrib><creatorcontrib>Rijs, A. J.</creatorcontrib><creatorcontrib>Verweij, P. E.</creatorcontrib><title>In vitro activity of amphotericin B and itraconazole in combination with flucytosine, sulfadiazine and quinolones against Exophiala spinifera</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J. Antimicrob. Chemother</addtitle><description>The combined effects of antifungal and antibiotic drugs against Exophiala spinifera were evaluated in vitro by the chequer-board method, calculated as a fractional inhibitory concentration (FIC) index. Amphotericin B was combined with flucytosine and ciprofloxacin, whereas itraconazole was combined with ciprofloxacin, levofloxacin, lomefloxacin and sulfadiazine. Synergic effects were observed for the combinations of itraconazole with ciprofloxacin and levofloxacin, and amphotericin B with ciprofloxacin and flucytosine. No antagonism was observed for any combination tested.</description><subject>Amphotericin B - pharmacology</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>black yeasts</subject><subject>Drug Combinations</subject><subject>Exophiala</subject><subject>Exophiala - drug effects</subject><subject>Exophiala spinifera</subject><subject>Flucytosine - pharmacology</subject><subject>Itraconazole - pharmacology</subject><subject>lomefloxacin</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. 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| subjects | Amphotericin B - pharmacology Anti-Infective Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - pharmacology Biological and medical sciences black yeasts Drug Combinations Exophiala Exophiala - drug effects Exophiala spinifera Flucytosine - pharmacology Itraconazole - pharmacology lomefloxacin Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments quinolones Quinolones - pharmacology Sulfadiazine - pharmacology |
| title | In vitro activity of amphotericin B and itraconazole in combination with flucytosine, sulfadiazine and quinolones against Exophiala spinifera |
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