Hypertonicity Activates Na+/H+ Exchange through Janus Kinase 2 and Calmodulin

The type 1 sodium-hydrogen exchanger (NHE-1) is a ubiquitous electroneutral membrane transporter that is activated by hypertonicity in many cells. NHE-1 may be an important pathway for Na+ entry during volume restoration, yet the molecular mechanisms underlying the osmotic regulation of NHE-1 are po...

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Veröffentlicht in:	The Journal of biological chemistry 2003-05, Vol.278 (19), p.16908-16915
Hauptverfasser:	Garnovskaya, Maria N., Mukhin, Yurii V., Vlasova, Tamara M., Raymond, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calmodulin - metabolism CHO Cells Cricetinae Enzyme Activation Hydrogen - metabolism Hydrogen-Ion Concentration Ion Transport - physiology Janus Kinase 2 Membrane Proteins - metabolism Phosphorylation Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins Sodium - metabolism Sodium-Hydrogen Exchangers - metabolism
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