TBARS, carnitine, and reduced glutathione levels in human bladder carcinoma
In this study, we investigated tissue levels of reduced glutathione (GSH) and carnitine as well as thiobarbituric acid reactive substances (TBARS, as a marker of lipid peroxidation) levels in bladder carcinoma and control group of patients. The average GSH, carnitine and TBARS levels for tumor group...
Gespeichert in:
| Veröffentlicht in: | Biochemistry (Moscow) 2003-03, Vol.68 (3), p.346-348 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 348 |
|---|---|
| container_issue | 3 |
| container_start_page | 346 |
| container_title | Biochemistry (Moscow) |
| container_volume | 68 |
| creator | Sönmez, H Ozturk, Z Ekmekci, H Baloglu, H Kökoglu, E |
| description | In this study, we investigated tissue levels of reduced glutathione (GSH) and carnitine as well as thiobarbituric acid reactive substances (TBARS, as a marker of lipid peroxidation) levels in bladder carcinoma and control group of patients. The average GSH, carnitine and TBARS levels for tumor group were respectively 7.11 +/- 3.3 micro g/mg protein, 1.81 +/- 0.39 nmol/mg protein, and 4.29 +/- 3.2 micro mol/mg protein, versus 14.45 +/- 4.11 micro g/mg protein, 2.14 +/- 0.66 nmol/mg protein, and 2.3 +/- 0.6 micro mol/mg protein for normal bladder tissues. Thus, tissue reduced glutathione levels (GSH) were significantly lower in patients as compared with the control group (p < 0.001) whereas average TBARS levels in the tumor group were found to be higher than those in control group. The average tissue carnitine levels in the patient group were found to be lower compared with the control group but the difference was not statistically significant (p > 0.05). |
| doi_str_mv | 10.1023/A:1023018620047 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_73248972</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2092557851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c280t-c98353e72d0294af2a8c8acb370d2b4b6130d48af3effcacf1f121a7ef373dca3</originalsourceid><addsrcrecordid>eNpdkMtLw0AYxBdRbK2evcniwVOj3-6XZjfeavGFBUHrOXzZh01JNpqH4H9vivXiaRj4zTAMY6cCLgVIvJpfbwWETiRArPbYWCSgI4QY9tkYAJJIpiodsaO23QxWQoqHbCSkQkyVHrOn1c385XXKDTWh6IrgppyC5Y2zvXGWv5d9R926qIPjpftyZcuLwNd9RYHnJVnrmm3UFKGu6JgdeCpbd7LTCXu7u10tHqLl8_3jYr6MjNTQRSbVOEOnpAWZxuQlaaPJ5KjAyjzOE4FgY00enfeGjBdeSEHKeVRoDeGEXfz2fjT1Z-_aLquK1riypODqvs0UylinSg7g-T9wU_dNGLZlSko1A5XgAJ3toD6vnM0-mqKi5jv7-wh_AIsCZ-E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>722750763</pqid></control><display><type>article</type><title>TBARS, carnitine, and reduced glutathione levels in human bladder carcinoma</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Sönmez, H ; Ozturk, Z ; Ekmekci, H ; Baloglu, H ; Kökoglu, E</creator><creatorcontrib>Sönmez, H ; Ozturk, Z ; Ekmekci, H ; Baloglu, H ; Kökoglu, E</creatorcontrib><description>In this study, we investigated tissue levels of reduced glutathione (GSH) and carnitine as well as thiobarbituric acid reactive substances (TBARS, as a marker of lipid peroxidation) levels in bladder carcinoma and control group of patients. The average GSH, carnitine and TBARS levels for tumor group were respectively 7.11 +/- 3.3 micro g/mg protein, 1.81 +/- 0.39 nmol/mg protein, and 4.29 +/- 3.2 micro mol/mg protein, versus 14.45 +/- 4.11 micro g/mg protein, 2.14 +/- 0.66 nmol/mg protein, and 2.3 +/- 0.6 micro mol/mg protein for normal bladder tissues. Thus, tissue reduced glutathione levels (GSH) were significantly lower in patients as compared with the control group (p < 0.001) whereas average TBARS levels in the tumor group were found to be higher than those in control group. The average tissue carnitine levels in the patient group were found to be lower compared with the control group but the difference was not statistically significant (p > 0.05).</description><identifier>ISSN: 0006-2979</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1023/A:1023018620047</identifier><identifier>PMID: 12733978</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Acids ; Biomarkers, Tumor - metabolism ; Bladder ; Carnitine - metabolism ; Glutathione - metabolism ; Humans ; Lipid Peroxidation ; Oxidation-Reduction ; Peroxidation ; Proteins ; Thiobarbituric Acid Reactive Substances - metabolism ; Tissues ; Urinary Bladder Neoplasms - metabolism</subject><ispartof>Biochemistry (Moscow), 2003-03, Vol.68 (3), p.346-348</ispartof><rights>MAIK "Nauka/Interperiodica" 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-c98353e72d0294af2a8c8acb370d2b4b6130d48af3effcacf1f121a7ef373dca3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12733978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sönmez, H</creatorcontrib><creatorcontrib>Ozturk, Z</creatorcontrib><creatorcontrib>Ekmekci, H</creatorcontrib><creatorcontrib>Baloglu, H</creatorcontrib><creatorcontrib>Kökoglu, E</creatorcontrib><title>TBARS, carnitine, and reduced glutathione levels in human bladder carcinoma</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry (Mosc)</addtitle><description>In this study, we investigated tissue levels of reduced glutathione (GSH) and carnitine as well as thiobarbituric acid reactive substances (TBARS, as a marker of lipid peroxidation) levels in bladder carcinoma and control group of patients. The average GSH, carnitine and TBARS levels for tumor group were respectively 7.11 +/- 3.3 micro g/mg protein, 1.81 +/- 0.39 nmol/mg protein, and 4.29 +/- 3.2 micro mol/mg protein, versus 14.45 +/- 4.11 micro g/mg protein, 2.14 +/- 0.66 nmol/mg protein, and 2.3 +/- 0.6 micro mol/mg protein for normal bladder tissues. Thus, tissue reduced glutathione levels (GSH) were significantly lower in patients as compared with the control group (p < 0.001) whereas average TBARS levels in the tumor group were found to be higher than those in control group. The average tissue carnitine levels in the patient group were found to be lower compared with the control group but the difference was not statistically significant (p > 0.05).</description><subject>Acids</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Bladder</subject><subject>Carnitine - metabolism</subject><subject>Glutathione - metabolism</subject><subject>Humans</subject><subject>Lipid Peroxidation</subject><subject>Oxidation-Reduction</subject><subject>Peroxidation</subject><subject>Proteins</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Tissues</subject><subject>Urinary Bladder Neoplasms - metabolism</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkMtLw0AYxBdRbK2evcniwVOj3-6XZjfeavGFBUHrOXzZh01JNpqH4H9vivXiaRj4zTAMY6cCLgVIvJpfbwWETiRArPbYWCSgI4QY9tkYAJJIpiodsaO23QxWQoqHbCSkQkyVHrOn1c385XXKDTWh6IrgppyC5Y2zvXGWv5d9R926qIPjpftyZcuLwNd9RYHnJVnrmm3UFKGu6JgdeCpbd7LTCXu7u10tHqLl8_3jYr6MjNTQRSbVOEOnpAWZxuQlaaPJ5KjAyjzOE4FgY00enfeGjBdeSEHKeVRoDeGEXfz2fjT1Z-_aLquK1riypODqvs0UylinSg7g-T9wU_dNGLZlSko1A5XgAJ3toD6vnM0-mqKi5jv7-wh_AIsCZ-E</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Sönmez, H</creator><creator>Ozturk, Z</creator><creator>Ekmekci, H</creator><creator>Baloglu, H</creator><creator>Kökoglu, E</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>TBARS, carnitine, and reduced glutathione levels in human bladder carcinoma</title><author>Sönmez, H ; Ozturk, Z ; Ekmekci, H ; Baloglu, H ; Kökoglu, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-c98353e72d0294af2a8c8acb370d2b4b6130d48af3effcacf1f121a7ef373dca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acids</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Bladder</topic><topic>Carnitine - metabolism</topic><topic>Glutathione - metabolism</topic><topic>Humans</topic><topic>Lipid Peroxidation</topic><topic>Oxidation-Reduction</topic><topic>Peroxidation</topic><topic>Proteins</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Tissues</topic><topic>Urinary Bladder Neoplasms - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sönmez, H</creatorcontrib><creatorcontrib>Ozturk, Z</creatorcontrib><creatorcontrib>Ekmekci, H</creatorcontrib><creatorcontrib>Baloglu, H</creatorcontrib><creatorcontrib>Kökoglu, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemistry (Moscow)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sönmez, H</au><au>Ozturk, Z</au><au>Ekmekci, H</au><au>Baloglu, H</au><au>Kökoglu, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TBARS, carnitine, and reduced glutathione levels in human bladder carcinoma</atitle><jtitle>Biochemistry (Moscow)</jtitle><addtitle>Biochemistry (Mosc)</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>68</volume><issue>3</issue><spage>346</spage><epage>348</epage><pages>346-348</pages><issn>0006-2979</issn><eissn>1608-3040</eissn><abstract>In this study, we investigated tissue levels of reduced glutathione (GSH) and carnitine as well as thiobarbituric acid reactive substances (TBARS, as a marker of lipid peroxidation) levels in bladder carcinoma and control group of patients. The average GSH, carnitine and TBARS levels for tumor group were respectively 7.11 +/- 3.3 micro g/mg protein, 1.81 +/- 0.39 nmol/mg protein, and 4.29 +/- 3.2 micro mol/mg protein, versus 14.45 +/- 4.11 micro g/mg protein, 2.14 +/- 0.66 nmol/mg protein, and 2.3 +/- 0.6 micro mol/mg protein for normal bladder tissues. Thus, tissue reduced glutathione levels (GSH) were significantly lower in patients as compared with the control group (p < 0.001) whereas average TBARS levels in the tumor group were found to be higher than those in control group. The average tissue carnitine levels in the patient group were found to be lower compared with the control group but the difference was not statistically significant (p > 0.05).</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>12733978</pmid><doi>10.1023/A:1023018620047</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-2979 |
| ispartof | Biochemistry (Moscow), 2003-03, Vol.68 (3), p.346-348 |
| issn | 0006-2979 1608-3040 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73248972 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acids Biomarkers, Tumor - metabolism Bladder Carnitine - metabolism Glutathione - metabolism Humans Lipid Peroxidation Oxidation-Reduction Peroxidation Proteins Thiobarbituric Acid Reactive Substances - metabolism Tissues Urinary Bladder Neoplasms - metabolism |
| title | TBARS, carnitine, and reduced glutathione levels in human bladder carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T23%3A34%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TBARS,%20carnitine,%20and%20reduced%20glutathione%20levels%20in%20human%20bladder%20carcinoma&rft.jtitle=Biochemistry%20(Moscow)&rft.au=S%C3%B6nmez,%20H&rft.date=2003-03-01&rft.volume=68&rft.issue=3&rft.spage=346&rft.epage=348&rft.pages=346-348&rft.issn=0006-2979&rft.eissn=1608-3040&rft_id=info:doi/10.1023/A:1023018620047&rft_dat=%3Cproquest_pubme%3E2092557851%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=722750763&rft_id=info:pmid/12733978&rfr_iscdi=true |