Pseudononapeptide bombesin antagonists containing C-terminal Trp or Tpi

Seven new antagonists of bombesin (Bn)/gastrin-releasing peptide (GRP) containing C-terminal Trp or Tpi (2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-3-carboxylic acid) in a reduced peptide bond were synthesized by solid phase methods and evaluated biologically. The reduced bond in four [Leu 13ψ(CH 2NH)...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1992-03, Vol.13 (2), p.267-271
Hauptverfasser:	Cai, Ren-Zhi, Radulovic, Sinisa, Pinski, Jacek, Nagy, Attila, Redding, Tommie W., Olsen, Donald B., Schally, Andrew V.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals antagonists Biological and medical sciences bombesin Bombesin - analogs & derivatives Bombesin - antagonists & inhibitors Bombesin antagonist C-terminal Fundamental and applied biological sciences. Psychology Mice Molecular Sequence Data New reduced bond Tpi Oligopeptides - chemical synthesis Oligopeptides - pharmacology Peptide Fragments - chemical synthesis Peptide Fragments - pharmacology Protein Conformation Proteins Pseudononapeptide Solid phase synthesis Structure-Activity Relationship tryptophan Tryptophan - chemistry
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