Immunopurification and Characterization of Rat Adipocyte Caveolae Suggest Their Dissociation from Insulin Signaling

Adipocytes play an important role in the insulin-dependent regulation of organismal fuel metabolism and express caveolae at levels as high or higher than any other cell type. Recently, a link between insulin signaling and caveolae has been suggested; nevertheless, adipocyte caveolae have been the su...

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Veröffentlicht in:	The Journal of biological chemistry 2003-05, Vol.278 (20), p.18321-18329
Hauptverfasser:	Souto, Ricardo P, Vallega, Gino, Wharton, Jonathan, Vinten, Jorgen, Tranum-Jensen, Jorgen, Pilch, Paul F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - metabolism Animals Antibodies, Monoclonal - metabolism Biotinylation Blotting, Western Caveolae - metabolism Caveolin 1 Caveolins - metabolism CD36 Antigens - metabolism Cell Membrane - metabolism Electrophoresis, Polyacrylamide Gel Immunohistochemistry Insulin - metabolism Membrane Microdomains - metabolism Membrane Proteins - metabolism Microscopy, Fluorescence Models, Biological Precipitin Tests Rats Receptor, Insulin - metabolism Signal Transduction Subcellular Fractions
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