On the confirmation of an effect of magnetic fields on the interictal firing rate of epileptic patients
The effect of magnetic fields on interictal firing rates was investigated in three epileptic patients with depth electrode implantation in the hippocampus for pre-surgical evaluation. The protocol consisted of 10 min test periods, during which magnetic fields were cycled for 1 min on and 1 min off,...
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| Veröffentlicht in: | Brain research bulletin 2003-04, Vol.60 (1), p.43-52 |
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| creator | Fuller, M. Wilson, C.L. Velasco, A.L. Dunn, J.R. Zoeger, J. |
| description | The effect of magnetic fields on interictal firing rates was investigated in three epileptic patients with depth electrode implantation in the hippocampus for pre-surgical evaluation. The protocol consisted of 10
min test periods, during which magnetic fields were cycled for 1
min on and 1
min off, and intervening 5
min rest periods. Only one patient revealed a 95% significant increase in the10
s after the fields were switched on compared with the background estimate from the 10
s before the fields were applied. This patient was also the only patient to show significant increases in firing rates during field-on compared with field-off periods, and during magnetic field test periods compared with intervening rest periods. This patient had a right hippocampal seizure onset. All patients showed increased firing rates during the 10
min periods of magnetic field testing compared to the 5
min rest periods between tests. This result was significant for the group at the 99% level. Two patients with right temporal lobe onset showed greater activity in the right hippocampus than the left. All patients exhibited a progressive increase in firing rates in rest periods between tests. |
| doi_str_mv | 10.1016/S0361-9230(03)00027-3 |
| format | Article |
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min test periods, during which magnetic fields were cycled for 1
min on and 1
min off, and intervening 5
min rest periods. Only one patient revealed a 95% significant increase in the10
s after the fields were switched on compared with the background estimate from the 10
s before the fields were applied. This patient was also the only patient to show significant increases in firing rates during field-on compared with field-off periods, and during magnetic field test periods compared with intervening rest periods. This patient had a right hippocampal seizure onset. All patients showed increased firing rates during the 10
min periods of magnetic field testing compared to the 5
min rest periods between tests. This result was significant for the group at the 99% level. Two patients with right temporal lobe onset showed greater activity in the right hippocampus than the left. All patients exhibited a progressive increase in firing rates in rest periods between tests.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/S0361-9230(03)00027-3</identifier><identifier>PMID: 12725891</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Electrodes, Implanted ; Electroencephalography - methods ; Electromagnetic Fields ; Electromagnetic Phenomena ; Epilepsy ; Epilepsy - physiopathology ; Evocation ; Evoked Potentials - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - anatomy & histology ; Hippocampus - physiopathology ; Humans ; Interictal activity ; Magnetic fields ; Male ; Time Factors</subject><ispartof>Brain research bulletin, 2003-04, Vol.60 (1), p.43-52</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-c37df233f90467cee3f9d6dba3c20e4811a4a0d1e5f9e1f79ce84f60df8037553</citedby><cites>FETCH-LOGICAL-c391t-c37df233f90467cee3f9d6dba3c20e4811a4a0d1e5f9e1f79ce84f60df8037553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0361-9230(03)00027-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14768833$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12725891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuller, M.</creatorcontrib><creatorcontrib>Wilson, C.L.</creatorcontrib><creatorcontrib>Velasco, A.L.</creatorcontrib><creatorcontrib>Dunn, J.R.</creatorcontrib><creatorcontrib>Zoeger, J.</creatorcontrib><title>On the confirmation of an effect of magnetic fields on the interictal firing rate of epileptic patients</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>The effect of magnetic fields on interictal firing rates was investigated in three epileptic patients with depth electrode implantation in the hippocampus for pre-surgical evaluation. The protocol consisted of 10
min test periods, during which magnetic fields were cycled for 1
min on and 1
min off, and intervening 5
min rest periods. Only one patient revealed a 95% significant increase in the10
s after the fields were switched on compared with the background estimate from the 10
s before the fields were applied. This patient was also the only patient to show significant increases in firing rates during field-on compared with field-off periods, and during magnetic field test periods compared with intervening rest periods. This patient had a right hippocampal seizure onset. All patients showed increased firing rates during the 10
min periods of magnetic field testing compared to the 5
min rest periods between tests. This result was significant for the group at the 99% level. Two patients with right temporal lobe onset showed greater activity in the right hippocampus than the left. All patients exhibited a progressive increase in firing rates in rest periods between tests.</description><subject>Biological and medical sciences</subject><subject>Electrodes, Implanted</subject><subject>Electroencephalography - methods</subject><subject>Electromagnetic Fields</subject><subject>Electromagnetic Phenomena</subject><subject>Epilepsy</subject><subject>Epilepsy - physiopathology</subject><subject>Evocation</subject><subject>Evoked Potentials - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - anatomy & histology</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Interictal activity</subject><subject>Magnetic fields</subject><subject>Male</subject><subject>Time Factors</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPxCAYRYnROOPjJ2i60eiiCqUt7cqYia9kklmoa8LAx4hpaQXGxH8vnU6cpRse4dz7kYPQGcE3BJPy9hXTkqR1RvEVptcY44yldA9NScVomrGc7aPpHzJBR95_RqisivIQTUjGsqKqyRStFjYJH5DIzmrjWhFMZ5NOJ8ImoDXIMFxasbIQjEy0gUb5pBszxgZwRgbRxAdn7CpxIsAQgN400A-JPjaCDf4EHWjReDjd7sfo_fHhbfaczhdPL7P7eSppTUJcmdIZpbrGeckkQDypUi0FlRmGvCJE5AIrAoWugWhWS6hyXWKlK0xZUdBjdDn29q77WoMPvDVeQtMIC93ac0aznOUFjmAxgtJ13jvQvHemFe6HE8wHw3xjmA_6OKZ8Y5jTmDvfDlgvW1C71FZpBC62gPBSNNoJK43fcTkrq4oORXcjB1HHtwHHvYyqJCjjoneuOvPPV34BweiYlA</recordid><startdate>20030415</startdate><enddate>20030415</enddate><creator>Fuller, M.</creator><creator>Wilson, C.L.</creator><creator>Velasco, A.L.</creator><creator>Dunn, J.R.</creator><creator>Zoeger, J.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030415</creationdate><title>On the confirmation of an effect of magnetic fields on the interictal firing rate of epileptic patients</title><author>Fuller, M. ; Wilson, C.L. ; Velasco, A.L. ; Dunn, J.R. ; Zoeger, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-c37df233f90467cee3f9d6dba3c20e4811a4a0d1e5f9e1f79ce84f60df8037553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Electrodes, Implanted</topic><topic>Electroencephalography - methods</topic><topic>Electromagnetic Fields</topic><topic>Electromagnetic Phenomena</topic><topic>Epilepsy</topic><topic>Epilepsy - physiopathology</topic><topic>Evocation</topic><topic>Evoked Potentials - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - anatomy & histology</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Interictal activity</topic><topic>Magnetic fields</topic><topic>Male</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuller, M.</creatorcontrib><creatorcontrib>Wilson, C.L.</creatorcontrib><creatorcontrib>Velasco, A.L.</creatorcontrib><creatorcontrib>Dunn, J.R.</creatorcontrib><creatorcontrib>Zoeger, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuller, M.</au><au>Wilson, C.L.</au><au>Velasco, A.L.</au><au>Dunn, J.R.</au><au>Zoeger, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the confirmation of an effect of magnetic fields on the interictal firing rate of epileptic patients</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>2003-04-15</date><risdate>2003</risdate><volume>60</volume><issue>1</issue><spage>43</spage><epage>52</epage><pages>43-52</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>The effect of magnetic fields on interictal firing rates was investigated in three epileptic patients with depth electrode implantation in the hippocampus for pre-surgical evaluation. The protocol consisted of 10
min test periods, during which magnetic fields were cycled for 1
min on and 1
min off, and intervening 5
min rest periods. Only one patient revealed a 95% significant increase in the10
s after the fields were switched on compared with the background estimate from the 10
s before the fields were applied. This patient was also the only patient to show significant increases in firing rates during field-on compared with field-off periods, and during magnetic field test periods compared with intervening rest periods. This patient had a right hippocampal seizure onset. All patients showed increased firing rates during the 10
min periods of magnetic field testing compared to the 5
min rest periods between tests. This result was significant for the group at the 99% level. Two patients with right temporal lobe onset showed greater activity in the right hippocampus than the left. All patients exhibited a progressive increase in firing rates in rest periods between tests.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12725891</pmid><doi>10.1016/S0361-9230(03)00027-3</doi><tpages>10</tpages></addata></record> |
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| ispartof | Brain research bulletin, 2003-04, Vol.60 (1), p.43-52 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Electrodes, Implanted Electroencephalography - methods Electromagnetic Fields Electromagnetic Phenomena Epilepsy Epilepsy - physiopathology Evocation Evoked Potentials - physiology Female Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - anatomy & histology Hippocampus - physiopathology Humans Interictal activity Magnetic fields Male Time Factors |
| title | On the confirmation of an effect of magnetic fields on the interictal firing rate of epileptic patients |
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