Evaluation of β-adrenergic receptor subtypes in the human prostate cancer cell line-LNCaP

The present study was undertaken to determine the effects of catecholamines, agonists, and antagonists of β-adrenergic receptors (AR) in the LNCaP cell line. Changes in cellular cyclic adenosine-3′,5′-monophosphate (cAMP) levels were quantified by the use of a 6 cAMP response element (CRE)-luciferas...

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Veröffentlicht in:	Biochemical pharmacology 2003-05, Vol.65 (9), p.1489-1494
Hauptverfasser:	Nagmani, Rangaswamy, Pasco, David S., Salas, Ruben D., Feller, Dennis R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Biological and medical sciences cAMP Human β-adrenergic receptors Humans LNCaP Luciferase Male Medical sciences Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Adrenergic, beta - classification Receptors, Adrenergic, beta - drug effects Reporter gene assay Tumor Cells, Cultured
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