Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4

Leukotrienes (LTs) are 5-lipoxygenase (5-LO)-derived arachidonic metabolites that constitute a potent set of lipid mediators produced by inflammatory cells. Leukotriene A(4), a labile allylic epoxide formed from arachidonic acid by dual 5-LO activity, is the precursor for LTB(4) and LTC(4) synthesis...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2003-05, Vol.413 (2), p.158-163
Hauptverfasser:	Reddanna, Pallu, Prabhu, K Sandeep, Whelan, Jay, Reddy, C Channa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Animals Arachidonate 5-Lipoxygenase - metabolism Carboxypeptidases - pharmacology Carboxypeptidases A Cations Cattle Chromatography, High Pressure Liquid gamma-Glutamyltransferase - metabolism Hydrolysis Leukotriene C4 - metabolism Mass Spectrometry Models, Chemical SRS-A - analogs & derivatives SRS-A - metabolism Swine Time Factors Zinc - metabolism
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