Bauhinia proteinase inhibitor-based synthetic fluorogenic substrates for enzymes isolated from insect midgut and caterpillar bristles

Bauhinia ungulata factor Xa inhibitor (BuXI) inactivates factor Xa and LOPAP, a prothrombin activator proteinase isolated from the venom of Lonomia obliqua caterpillar bristles. The reactive site of the enzyme-inhibitor interaction was explored to design specific substrates for both enzymes. Methion...

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Veröffentlicht in:	Biological chemistry 2003-03, Vol.384 (3), p.489-492
Hauptverfasser:	Andrade, Sonia A, Santomauro-Vaz, Eugênio M, Lopes, Adriana R, Chudzinski-Tavassi, Ana M, Juliano, Maria A, Terra, Walter R, Sampaio, Misako U, Sampaio, Claudio A M, Oliva, Maria Luiza V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bauhinia - chemistry Binding Sites Factor Xa - chemistry Factor Xa Inhibitors Fluorescent Dyes Insecta - enzymology Plant Proteins - isolation & purification Plant Proteins - metabolism Plant Proteins - pharmacology Protease Inhibitors - isolation & purification Protease Inhibitors - metabolism Protease Inhibitors - pharmacology Seeds - chemistry Substrate Specificity
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