Expression of the hyaluronan receptor RHAMM in endometrial carcinomas suggests a role in tumour progression and metastasis
Interactions of hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) have been proposed as being important in promoting tumour progression and dissemination. This comparative study was designed to investigate the RHAMM expression patterns in endometrial carcinoma....
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2003-03, Vol.129 (3), p.161-164 |
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| creator | REIN, D. T ROEHRIG, K SCHÖNDORF, T LAZAR, A FLEISCH, M NIEDERACHER, D BENDER, H. G DALL, P |
| description | Interactions of hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) have been proposed as being important in promoting tumour progression and dissemination. This comparative study was designed to investigate the RHAMM expression patterns in endometrial carcinoma.
We examined a series of 89 endometrial carcinomas and 15 normal endometrial tissues by immunohistochemistry, using a RHAMM-specific polyclonal antibody. Expression of RHAMM was assessed according to the pattern and intensity within (overall cytoplasm, center/periphery of tumours) and between the tumours. The staining results were compared to the corresponding clinical data (age, menopause status, histological staining, histological grading, lymph node status).
RHAMM-expression was detectable in 58% of the 89 tumours [Histological stage: pT1a (8/12); pT1b (16/37); pT1c (18/26); pT2 (6/9); pT3a (4/5)] and 13% (2/15) of the normal endometrial tissues. The positivity rates for RHAMM were 100% in patients with positive lymph nodes but only 50.7% in patients with negative lymph nodes ( P |
| doi_str_mv | 10.1007/s00432-003-0415-0 |
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We examined a series of 89 endometrial carcinomas and 15 normal endometrial tissues by immunohistochemistry, using a RHAMM-specific polyclonal antibody. Expression of RHAMM was assessed according to the pattern and intensity within (overall cytoplasm, center/periphery of tumours) and between the tumours. The staining results were compared to the corresponding clinical data (age, menopause status, histological staining, histological grading, lymph node status).
RHAMM-expression was detectable in 58% of the 89 tumours [Histological stage: pT1a (8/12); pT1b (16/37); pT1c (18/26); pT2 (6/9); pT3a (4/5)] and 13% (2/15) of the normal endometrial tissues. The positivity rates for RHAMM were 100% in patients with positive lymph nodes but only 50.7% in patients with negative lymph nodes ( P<0-01). Additionally, the expression pattern showed a highly significant correlation ( P<0.01) with the histological grade of the tumours [G1 (6/42), G2 (33/34), G3 (13/13)] and occurrence of lymph node metastases.
Our results suggest that RHAMM expression may enhance and improve the invasion and metastasis of endometrial carcinomas.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-003-0415-0</identifier><identifier>PMID: 12712331</identifier><identifier>CODEN: JCROD7</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adenocarcinoma, Clear Cell - metabolism ; Adenocarcinoma, Clear Cell - pathology ; Adenocarcinoma, Papillary - metabolism ; Adenocarcinoma, Papillary - pathology ; Biological and medical sciences ; Cancer ; Carcinosarcoma - metabolism ; Carcinosarcoma - pathology ; Case-Control Studies ; Cell Division ; Cystadenocarcinoma, Serous - metabolism ; Cystadenocarcinoma, Serous - pathology ; Endometrial Neoplasms - metabolism ; Endometrial Neoplasms - pathology ; Endometrium - metabolism ; Extracellular Matrix Proteins - metabolism ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Hyaluronan Receptors - metabolism ; Immunoenzyme Techniques ; Lymphatic Metastasis ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness ; Oncology ; Prognosis ; Proteins ; Survival Rate ; Tumors</subject><ispartof>Journal of cancer research and clinical oncology, 2003-03, Vol.129 (3), p.161-164</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-2f2d6155a8ded80d61bbfb241d37da0bc34701e0325a8c57af238b66f7ccdbc03</citedby><cites>FETCH-LOGICAL-c354t-2f2d6155a8ded80d61bbfb241d37da0bc34701e0325a8c57af238b66f7ccdbc03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14762072$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12712331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>REIN, D. T</creatorcontrib><creatorcontrib>ROEHRIG, K</creatorcontrib><creatorcontrib>SCHÖNDORF, T</creatorcontrib><creatorcontrib>LAZAR, A</creatorcontrib><creatorcontrib>FLEISCH, M</creatorcontrib><creatorcontrib>NIEDERACHER, D</creatorcontrib><creatorcontrib>BENDER, H. G</creatorcontrib><creatorcontrib>DALL, P</creatorcontrib><title>Expression of the hyaluronan receptor RHAMM in endometrial carcinomas suggests a role in tumour progression and metastasis</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><description>Interactions of hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) have been proposed as being important in promoting tumour progression and dissemination. This comparative study was designed to investigate the RHAMM expression patterns in endometrial carcinoma.
We examined a series of 89 endometrial carcinomas and 15 normal endometrial tissues by immunohistochemistry, using a RHAMM-specific polyclonal antibody. Expression of RHAMM was assessed according to the pattern and intensity within (overall cytoplasm, center/periphery of tumours) and between the tumours. The staining results were compared to the corresponding clinical data (age, menopause status, histological staining, histological grading, lymph node status).
RHAMM-expression was detectable in 58% of the 89 tumours [Histological stage: pT1a (8/12); pT1b (16/37); pT1c (18/26); pT2 (6/9); pT3a (4/5)] and 13% (2/15) of the normal endometrial tissues. The positivity rates for RHAMM were 100% in patients with positive lymph nodes but only 50.7% in patients with negative lymph nodes ( P<0-01). Additionally, the expression pattern showed a highly significant correlation ( P<0.01) with the histological grade of the tumours [G1 (6/42), G2 (33/34), G3 (13/13)] and occurrence of lymph node metastases.
Our results suggest that RHAMM expression may enhance and improve the invasion and metastasis of endometrial carcinomas.</description><subject>Adenocarcinoma, Clear Cell - metabolism</subject><subject>Adenocarcinoma, Clear Cell - pathology</subject><subject>Adenocarcinoma, Papillary - metabolism</subject><subject>Adenocarcinoma, Papillary - pathology</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Carcinosarcoma - metabolism</subject><subject>Carcinosarcoma - pathology</subject><subject>Case-Control Studies</subject><subject>Cell Division</subject><subject>Cystadenocarcinoma, Serous - metabolism</subject><subject>Cystadenocarcinoma, Serous - pathology</subject><subject>Endometrial Neoplasms - metabolism</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrium - metabolism</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. 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Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hyaluronan Receptors - metabolism</topic><topic>Immunoenzyme Techniques</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>REIN, D. T</creatorcontrib><creatorcontrib>ROEHRIG, K</creatorcontrib><creatorcontrib>SCHÖNDORF, T</creatorcontrib><creatorcontrib>LAZAR, A</creatorcontrib><creatorcontrib>FLEISCH, M</creatorcontrib><creatorcontrib>NIEDERACHER, D</creatorcontrib><creatorcontrib>BENDER, H. 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T</au><au>ROEHRIG, K</au><au>SCHÖNDORF, T</au><au>LAZAR, A</au><au>FLEISCH, M</au><au>NIEDERACHER, D</au><au>BENDER, H. G</au><au>DALL, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of the hyaluronan receptor RHAMM in endometrial carcinomas suggests a role in tumour progression and metastasis</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>129</volume><issue>3</issue><spage>161</spage><epage>164</epage><pages>161-164</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><coden>JCROD7</coden><abstract>Interactions of hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) have been proposed as being important in promoting tumour progression and dissemination. This comparative study was designed to investigate the RHAMM expression patterns in endometrial carcinoma.
We examined a series of 89 endometrial carcinomas and 15 normal endometrial tissues by immunohistochemistry, using a RHAMM-specific polyclonal antibody. Expression of RHAMM was assessed according to the pattern and intensity within (overall cytoplasm, center/periphery of tumours) and between the tumours. The staining results were compared to the corresponding clinical data (age, menopause status, histological staining, histological grading, lymph node status).
RHAMM-expression was detectable in 58% of the 89 tumours [Histological stage: pT1a (8/12); pT1b (16/37); pT1c (18/26); pT2 (6/9); pT3a (4/5)] and 13% (2/15) of the normal endometrial tissues. The positivity rates for RHAMM were 100% in patients with positive lymph nodes but only 50.7% in patients with negative lymph nodes ( P<0-01). Additionally, the expression pattern showed a highly significant correlation ( P<0.01) with the histological grade of the tumours [G1 (6/42), G2 (33/34), G3 (13/13)] and occurrence of lymph node metastases.
Our results suggest that RHAMM expression may enhance and improve the invasion and metastasis of endometrial carcinomas.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12712331</pmid><doi>10.1007/s00432-003-0415-0</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenocarcinoma, Clear Cell - metabolism Adenocarcinoma, Clear Cell - pathology Adenocarcinoma, Papillary - metabolism Adenocarcinoma, Papillary - pathology Biological and medical sciences Cancer Carcinosarcoma - metabolism Carcinosarcoma - pathology Case-Control Studies Cell Division Cystadenocarcinoma, Serous - metabolism Cystadenocarcinoma, Serous - pathology Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology Endometrium - metabolism Extracellular Matrix Proteins - metabolism Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Hyaluronan Receptors - metabolism Immunoenzyme Techniques Lymphatic Metastasis Medical sciences Middle Aged Neoplasm Invasiveness Oncology Prognosis Proteins Survival Rate Tumors |
| title | Expression of the hyaluronan receptor RHAMM in endometrial carcinomas suggests a role in tumour progression and metastasis |
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