Tyrosine phosphatase activity of lymphoma CD45 (GP180) is regulated by a direct interaction with the cytoskeleton

GP180 is one of the major transmembrane glycoproteins in mouse T-lymphoma cells. This molecule is an isoform of CD45 and is known to contain an intrinsic protein tyrosine phosphatase (PTPase) activity. Using several complementary biochemical techniques, we have found that fodrin (a spectrin-like pro...

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Veröffentlicht in:	The Journal of biological chemistry 1992-10, Vol.267 (30), p.21551-21557
Hauptverfasser:	Lokeshwar, V.B., Bourguignon, L.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Autoradiography Biological and medical sciences Carcinoma, Squamous Cell Carrier Proteins - metabolism CD45 antigen cytoskeleton Cytoskeleton - metabolism Electrophoresis, Polyacrylamide Gel ErbB Receptors - metabolism Fundamental and applied biological sciences. Psychology Glycoproteins Humans interaction Kinetics Leukocyte Common Antigens - metabolism lymphocytes T Lymphoma, T-Cell Mice Microfilament Proteins - metabolism Phosphorylation Protein Tyrosine Phosphatases - metabolism protein-tyrosine-phosphatase Proteins regulation Spectrin - metabolism Tumor Cells, Cultured
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