Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes

Transcription factors of the interferon regulatory factor (IRF) family have been identified as critical mediators of early inflammatory gene transcription in infected cells. We have shown previously that IRF-5, like IRF-3 and IRF-7, is a direct transducer of virus-mediated signaling and plays a role...

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Veröffentlicht in:	The Journal of biological chemistry 2003-05, Vol.278 (19), p.16630-16641
Hauptverfasser:	Barnes, Betsy J, Field, Ann E, Pitha-Rowe, Paula M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Cell Line Dimerization DNA-Binding Proteins - metabolism Gene Expression Regulation, Viral Humans Interferon Regulatory Factor-7 Interferon Regulatory Factors Interferon-alpha - genetics Interferon-alpha - metabolism Newcastle disease virus - physiology Sendai virus - physiology Transcription Factors - metabolism Transcriptional Activation
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