SHH and FGF8 play distinct roles during development of noradrenergic neurons in the locus coeruleus of the zebrafish

Several signaling pathways have been implicated in the development of dopaminergic and serotonergic neurons. Here, we analyzed the formation of noradrenergic (NAergic) cells in the locus coeruleus (LC) of zebrafish. In the sonic hedgehog (shh) mutant, cells positive for tyrosine hydroxylase, a marke...

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Veröffentlicht in:	Molecular and cellular neuroscience 2003-04, Vol.22 (4), p.501-515
Hauptverfasser:	Lam, Chen Sok, Sleptsova-Friedrich, Inna, Munro, Angus D, Korzh, Vladimir
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors, Type I - genetics Activin Receptors, Type I - metabolism Animals Apoptosis - genetics Bone Morphogenetic Protein Receptors, Type I Cell Survival - genetics Danio rerio Down-Regulation - genetics Embryo, Nonmammalian - cytology Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Fibroblast Growth Factor 8 Fibroblast Growth Factors - deficiency Fibroblast Growth Factors - genetics Gene Expression Regulation, Developmental - genetics Hedgehog Proteins Locus Coeruleus - cytology Locus Coeruleus - embryology Locus Coeruleus - metabolism Mutation - genetics Neurons - cytology Neurons - metabolism Norepinephrine - biosynthesis Protein Biosynthesis - drug effects Protein Biosynthesis - genetics Protein Synthesis Inhibitors - pharmacology Protein-Serine-Threonine Kinases Receptors, Growth Factor sonic hedgehog protein Trans-Activators - deficiency Trans-Activators - genetics Tyrosine 3-Monooxygenase - metabolism Up-Regulation - genetics Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism
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